Intravitreal triamcinolone compared with macular laser grid photocoagulation for the treatment of cystoid macular edema
Intravitreal triamcinolone compared with macular laser grid photocoagulation for the treatment of cystoid macular edema
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DOI：
10.1016/j.ajo.2005.05.021
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发表时间：
2005-10-01
影响因子：
4.2
通讯作者：
Reibaldi, A
中科院分区：
文献类型：
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作者：
Avitabile, T;Longo, A;Reibaldi, A
目的：评价玻璃体内注射曲安奈德(TA)、黄斑激光格栅光子凝固术(MLG)或联合应用(TA+MLG)治疗黄斑囊样水肿(CME)的疗效。设计：前瞻性、随机、干预、平行、三联临床试验。患者：糖尿病或视网膜静脉阻塞CME患者56例(63只眼)。手术方法：玻璃体内注射TA 4 mg 2只眼，MLG 21只眼，玻璃体内注射4 mg TA 20只眼，3个月后注射MLG。主要观察指标：最佳矫正视力(VA)、黄斑中心厚度(CMT)(光学相干断层扫描)和术后并发症。结果：平均随访9+/-2个月(6~12个月)。TA组基线VA和CMT分别为0.82+/-0.19和556+/-139微米，MLG组分别为0.84+/-0.15和601+/-102微米，TA+MLG组分别为0.83+/-0.22和573+/-106微米(组间差异无统计学意义)。治疗后45天、3个月、6个月和9个月时，TA组的视力均有改善(P=0.004)。0.26、0.25、0.22和0.23logMAR和CMT分别下降37%、33%、29%和31%(P=
PURPOSE: To evaluate the outcome of cystoid macular edema (CME) treated with intravitreal injections of triamcinolone acetonide (TA), macular laser grid photon coagulation (MLG), or both (TA+MLG).DESIGN: Prospective, randomized, interventional, parallel, three,arm clinical trial.METHODS: SETTING: Institutional clinical study. PATIENTS: Fifty-six patients (63 eyes) affected by diabetic or retinal vein occlusion CME. PROCEDURES: Twenty, two eyes received intravitreal injections of 4 mg TA; 21 eyes underwent MLG; and 20 eyes received intravitreal injection of 4 mg TA, and after 3 months, MLG. MAIN OUTCOME MEASURES: Best,corrected visual acuity (VA), central macular thickness (CMT) (by optical coherence tomography), and postoperative complications.RESULTS: Mean follow-up was 9 +/- 2 months (range 6 to 12 months). Baseline VA (logarithm of minimal angle of resolution [logMAR]) and CMT were, respectively, 0.82 +/- 0.19 and 556 +/- 139 mu m microns for the TA group, 0.84 +/- 0.15 and 601 +/- 102 mu m microns for the MLG group, and 0.83 +/- 0.22 and 573 +/- 106 mu m microns for the TA+MLG group (no statistically significant difference among the groups). After the treatment, at 45 days, 3, 6, and 9 months in the TA group, VA had improved (P =.004). by 0.26, 0.25, 0.22, and 0.23 logMAR and CMT had decreased by 37%, 33%, 29%, and 31% (P =