A prospective study on habitual duration of sleep and incidence of breast cancer in a large cohort of women
A prospective study on habitual duration of sleep and incidence of breast cancer in a large cohort of women
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DOI：
10.1158/0008-5472.can-05-4652
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发表时间：
2006-05-15
期刊：
影响因子：
11.2
通讯作者：
Michels, KB
中科院分区：
文献类型：
--
作者：
Pinheiro, SP;Schernhammer, ES;Michels, KB
越来越多的证据表明，习惯性睡眠时间与各种健康结果有关;睡眠时间短和长都与心血管疾病，糖尿病和全因死亡率的风险增加有关。然而，关于睡眠时间与癌症风险之间关系的数据很少，而且不确定。最近有人提出，褪黑激素（一种与睡眠密切相关的激素）水平低与乳腺癌风险增加之间存在联系，但尚不清楚睡眠时间是否会影响乳腺癌风险。我们使用考克斯比例风险模型探讨了1986年报道的习惯性睡眠时间与护士健康研究中随后乳腺癌风险之间的关系。在16年的随访中，该队列中的77，418名女性中发生了4，223例乳腺癌事件。与睡眠时间7小时的女性相比，睡眠时间≥ 9小时的女性的协变量调整风险比和95%置信区间分别为0.93（0.79-1.09）、0.98（0.91-1.06）、1.05（0.97-1.13）和0.95（0.82-1.11）。当分析仅限于1986年和2000年报告相同睡眠时间的参与者时，观察到睡眠时间延长的风险增加的中度趋势（P趋势= 0.05）。在这项前瞻性研究中，我们没有发现睡眠时间与乳腺癌发病率之间存在关联的令人信服的证据。
Mounting evidence suggests habitual sleep duration is associated with various health outcomes; both short and long sleep duration have been implicated in increased risk of cardiovascular disease, diabetes, and all-cause mortality. However, data on the relation between sleep duration and cancer risk are sparse and inconclusive. A link between low levels of melatonin, a hormone closely related to sleep, and increased risk of breast cancer has recently been suggested but it is unclear whether duration of sleep may affect breast cancer risk. We explored the association between habitual sleep duration reported in 1986 and subsequent risk of breast cancer in the Nurses' Health Study using Cox proportional hazards models. During 16 years of follow-up, 4,223 incident cases of breast cancer occurred among 77,418 women in this cohort. Compared with women sleeping 7 hours, covariate-adjusted hazard ratios and 95% confidence intervals for those sleeping = 9 hours were 0.93 (0.79-1.09), 0.98 (0.91-1.06), 1.05 (0.97-1.13), and 0.95 (0.82-1.11), respectively. A moderate trend in risk increase towards longer sleep duration was observed when analyses were restricted to participants who reported same sleep duration in 1986 and 2000 (P-trend = 0.05). In this prospective study, we found no convincing evidence for an association between sleep duration and the incidence of breast cancer.