Specific immunotherapy of advanced renal carcinoma: Evidence for the polyclonality of metastases
Specific immunotherapy of advanced renal carcinoma: Evidence for the polyclonality of metastases
复制标题
晚期肾癌的特异性免疫治疗：转移多克隆性的证据
作者：
C. McCune;D. Schapira;E. Henshaw
自体照射（10，000拉德）肿瘤细胞与C.对14例转移性肾癌患者每周给予一次parvum。肿瘤组织用DMSO冷冻保存。未产生明显毒性。4例患者出现客观缓解，第5例患者长期稳定（27个月以上）。不同的反应同时发生在同一患者的不同转移病灶。缓解的患者通常具有良好的行走状态，并且接受了大于20 × 107个肿瘤细胞。
Autologous, irradiated (10,000 rads) tumor cells mixed with C. parvumwere given weekly to 14 patients with metastatic renal carcinoma. The tumor tissue had been cryopreserved with DMSO. No significant toxicity was produced. Four patients underwent objective responses, and a fifth had prolonged stabilization (27+ months). Varying responses occurred simultaneously in different metastatic lesions within the same patient. Responding patients usually had an excellent ambulatory status and received greater than 20 × 107tumor cells.