Isolation of metronidazole-resistant Bacteroides fragilis carrying the nimA nitroreductase gene from a patient in Washington state
Isolation of metronidazole-resistant Bacteroides fragilis carrying the nimA nitroreductase gene from a patient in Washington state
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DOI：
10.1128/jcm.42.9.4127-4129.2004
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发表时间：
2004-09-01
影响因子：
9.4
通讯作者：
Limaye, AP
中科院分区：
文献类型：
--
作者：
Schapiro, JM;Gupta, R;Limaye, AP
脆弱拟杆菌群的成员是临床标本中最常见的厌氧菌分离株。甲硝唑是一种5-硝基咪唑，常用于厌氧菌感染的经验性治疗。由于拟杆菌属几乎普遍敏感，因此未常规进行药敏试验。这个探员我们报告了一例甲硝唑耐药脆弱拟杆菌在美国和证明存在的nimA基因，编码一种硝基还原酶先前显示介导耐药性5-硝基咪唑抗菌剂在B。来自欧洲和非洲的fragilis菌株。由于拟杆菌感染的临床失败与使用无活性的抗菌药物有关，临床医生需要了解甲硝唑耐药B的可能性。在美国的脆弱菌株和敏感性测试在选定的情况下的重要性。
Members of the Bacteroides fragilis group are among the most common anaerobic bacterial isolates in clinical specimens. Metronidazole, a 5-nitroimidazole, is often used as empirical therapy for anaerobic infections. Susceptibility testing is not routinely performed because of nearly universal susceptibility of Bacteroides spp. to this agent. We report a case of metronidazole-resistant Bacteroides fragilis in the United States and demonstrate the presence of the nimA gene, encoding a nitroreductase previously shown to mediate resistance to 5-nitroimidazole antimicrobial agents in B. fragilis strains from Europe and Africa. Because clinical failures in Bacteroides infections have been associated with the use of inactive antimicrobial agents, clinicians need to be aware of the possibility of metronidazole-resistant B. fragilis strains in the United States and the importance of susceptibility testing in selected situations.