Heritability of LDL peak particle diameter in the Quebec family study
Heritability of LDL peak particle diameter in the Quebec family study
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DOI：
10.1002/gepi.10272
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发表时间：
2003-12-01
影响因子：
2.1
通讯作者：
Pérusse, L
中科院分区：
文献类型：
--
作者：
Bossé, Y;Vohl, MC;Pérusse, L
低密度脂蛋白的大小与冠心病的风险有关。本研究的目的是验证家族因素是否影响 LDL 峰值粒径 (LDL-PPD)，这是反映主要 LDL 亚类大小的数量性状。通过 2-16% 聚丙烯酰胺梯度凝胶电泳对参与魁北克家庭研究的 236 个核心家庭的 681 名成员进行了 LDL-PPD 测量。男性和女性的 LDL-PPD 分别根据年龄 (LDL-PPD1)、年龄和体重指数 (LDL-PPD2) 或年龄、体重指数和血浆甘油三酯水平 (LDL-PPD3) 进行调整。残差分数用于使用方差分析来测试家族聚集，并计算家族相关性的最大似然估计。方差分析显示，家族谱系分别占 LDL-PPD1、LDL-PPD2 和 LDL-PPD3 表型方差的 47.4%、46.7% 和 48.9%。家族相关性模式显示，三种 LDL-PPD 表型没有显着的配偶相关性，但有显着的亲子和兄弟姐妹相关性，LDL-PPD1、LDL-PPD2 和 LDL-PPD3 的最大遗传力估计值分别为 59%、58% 和 52%。这些结果表明 LDL-PPD 在家庭中强烈聚集，并且家族相似性似乎主要归因于遗传因素。负责这种遗传贡献的基因仍有待确定。 (C) 2003 Wiley-Liss, Inc.
LDL size has been associated with the risk of coronary heart disease. The objective of the present study was to verify whether familial factors influence LDL peak particle diameter (LDL-PPD), a quantitative trait reflecting the size of the major LDL subclass. LDL-PPD was measured by 2-16% polyacrylamide gradient gel electrophoresis in 681 members of 236 nuclear families participating in the Quebec Family Study. LDL-PPD was adjusted for age (LDL-PPD1), age and body mass index (LDL-PPD2), or age, body mass index, and plasma triglyceride levels (LDL-PPD3) separately in men and women. The residual scores were used to test for familial aggregation, using an ANOVA and to compute maximum likelihood estimates of familial correlations. The ANOVA test revealed that family lines accounted for 47.4%, 46.7%, and 48.9% of the variance in the LDL-PPD1, LDL-PPD2, and LDL-PPD3 phenotypes, respectively. The pattern of familial correlations revealed no significant spouse correlations but significant parent-offspring and sibling correlations for the three LDL-PPD phenotypes, with maximal heritability estimates of 59%, 58%, and 52% for LDL-PPD1, LDL-PPD2, and LDL-PPD3, respectively. These results suggest that LDL-PPD strongly aggregates in families, and that the familial resemblance appears to be primarily attributable to genetic factors. Genes responsible for this genetic contribution remain to be identified. (C) 2003 Wiley-Liss, Inc.