EFFECTS OF DOPAMINERGIC AND GLUTAMATERGIC RECEPTOR ANTAGONISTS ON THE ACQUISITION AND EXPRESSION OF COCAINE CONDITIONING PLACE PREFERENCE
EFFECTS OF DOPAMINERGIC AND GLUTAMATERGIC RECEPTOR ANTAGONISTS ON THE ACQUISITION AND EXPRESSION OF COCAINE CONDITIONING PLACE PREFERENCE
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DOI：
10.1016/0006-8993(94)01420-m
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发表时间：
1995-03-06
期刊：
影响因子：
2.9
通讯作者：
SAMANIN, R
中科院分区：
文献类型：
--
作者：
CERVO, L;SAMANIN, R
采用平衡条件位置偏爱（CPP）实验范式，研究多巴胺D-1、D-2受体、多巴胺能NMDA受体和AMPA/红藻氨酸受体在可卡因位置条件反射获得和表达中的作用。在训练阶段在可卡因之前给药，显著阻断了位置条件反射的建立（获得），但在没有可卡因的情况下在位置偏好测试之前给药时没有效果（表达）。用非竞争性NMDA受体拮抗剂MK-801（0.1-0.5 mg/kg i. p.）获得了类似的结果。D-2受体拮抗剂（-）-舒必利（50-100 mg/kg i. p.）对可卡因CPP的获得或表达没有影响。AMPA/红藻氨酸受体拮抗剂DNQX，脑室内给药（0.2-3 μ g/10 μ l），当在测试前给药时，阻断了可卡因CPP，但在训练试验期间，在可卡因之前给药时没有阻断。（但不是D-2）和谷氨酸能NMDA受体参与可卡因的主要奖励特性（如通过CPP的建立所评估的），而AMPA/红藻氨酸受体仅对于由先前与药物作用相关的刺激引起的行为（CPP表达）是重要的。可卡因的渴望和复发的治疗的影响进行了讨论。
A balanced conditioning place preference (CPP) paradigm was used to study the role of dopamine D-1 and D-2 and glutamatergic NMDA and AMPA/kainate receptors on the acquisition and expression of cocaine place conditioning.The D-1 receptor antagonist SCH 23390 (0.1-0.2 mg/kg i.p.), administered before cocaine during the training phase, significantly blocked the establishment of place conditioning (acquisition) but had no effect when administered before testing for place preference in the absence of cocaine (expression). Similar results were obtained with the non-competitive NMDA receptor antagonist MK-801 (0.1-0.5 mg/kg i.p.). The D-2 receptor antagonist(-)-sulpiride (50-100 mg/kg i.p.) had no effect on either acquisition or expression of cocaine CPP. The AMPA/kainate receptor antagonist DNQX, administered intracerebroventricularly (0.2-3 mu g/10 mu l), blocked cocaine CPP when given before testing but not when given before cocaine during the training trials.The results suggest that dopaminergic D-1 (but not D-2) and glutamatergic NMDA receptors are involved in the primary rewarding properties of cocaine (as assessed by the establishment of CPP) whereas the AMPA/kainate receptors are important only for the behaviour elicited by the stimuli previously associated with the drug action (CPP expression). The implications for the treatment of cocaine craving and relapse are discussed.