1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose inhibits angiogenesis via inhibition of capillary morphogenesis gene 2.
1,2,3,4,6-Penta-O-galloyl-β-D-glucopyranose inhibits angiogenesis via inhibition of capillary morphogenesis gene 2.
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DOI：
10.1021/jm301558t
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发表时间：
2013-03-14
影响因子：
7.3
通讯作者：
Rogers, Michael S.
中科院分区：
文献类型：
--
作者：
Cryan, Lorna M.;Bazinet, Lauren;Habeshian, Kaiane A.;Cao, Shugeng;Clardy, Jon;Christensen, Kenneth A.;Rogers, Michael S.
CMG2 is a transmembrane extracellular matrix binding protein that is also an anthrax toxin receptor. We have shown that high affinity CMG2 binders can inhibit angiogenesis and tumor growth. We recently described a high throughput FRET assay to identify CMG2 inhibitors. We now report the serendipitous discovery that PGG (1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose) is a CMG2 inhibitor with anti-angiogenic activity. PGG is a gallotannin produced by a variety of medicinal plants that exhibits a wide variety of anti-tumor and other activities. We find that PGG inhibits CMG2 with a submicromolar IC50 and it also inhibits the migration of human dermal microvascular endothelial cells at similar concentrations in vitro. Finally, oral or intraperitoneal administration of PGG inhibits angiogenesis in the mouse corneal micropocket assay in vivo. Together, these results suggest that a portion of the in vivo anti-tumor activity of PGG may be the result of antiangiogenic activity mediated by inhibition of CMG2.
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影响因子：
3.7
作者：
Zhang J;Li L;Kim SH;Hagerman AE;Lü J
通讯作者：
Lü J
影响因子：
11.2
作者：
Rogers, Michael S.;Christensen, Kenneth A.;D'Amato, Robert J.
通讯作者：
D'Amato, Robert J.
影响因子：
5.4
作者：
Kiss, Andrea;Becsi, Balint;Erdodi, Ferenc
通讯作者：
Erdodi, Ferenc
影响因子：
2.7
作者：
Cao, Shugeng;Cryan, Lorna;Habeshian, Kaiane A.;Murillo, Catalina;Tamayo-Castillo, Giselle;Rogers, Michael S.;Clardy, Jon
通讯作者：
Clardy, Jon
影响因子：
5.8
作者：
Mizushina Y;Zhang J;Pugliese A;Kim SH;Lü J
通讯作者：
Lü J