Manganese ion chelated FeOCl@PB@PDA@BPQDs nanocomposites as a tumor microenvironment-mediated nanoplatform for enhanced tumor imaging and therapy
Manganese ion chelated FeOCl@PB@PDA@BPQDs nanocomposites as a tumor microenvironment-mediated nanoplatform for enhanced tumor imaging and therapy
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DOI：
10.1016/j.snb.2019.127491
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发表时间：
2020-03
影响因子：
8.4
通讯作者：
M. Zhang;M. Zhang;Bulei Sheng;J. Ashley;Tao Zheng;Wentao Wang;Qicheng Zhang;Jun Zhang;
中科院分区：
文献类型：
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作者：
M. Zhang;M. Zhang;Bulei Sheng;J. Ashley;Tao Zheng;Wentao Wang;Qicheng Zhang;Jun Zhang;
本文以普鲁士蓝（PB）、聚多巴胺（PDA）、黑磷量子点（BPQDs）和锰离子（Mn 2+）为载体，制备了一种新型的肿瘤微环境（TME）介导的纳米治疗诊断平台。在高度集成的纳米平台（FeOCl@PB@PDA@BPQDs@Mn）中，FeOCl催化剂通过H2 O2分解产生羟基自由基（·OH）用于化学动力学治疗（CDT）具有极高的效率。此外，PB、FeOCl和Mn ~（2+）具有过氧化氢酶样活性，可催化H_2O_2释放TME中的O_2。在激光照射下，BPQDs将O2转化为单线态氧（1 O2）以自我增强光动力学治疗（PDT）。此外，由于PB和PDA的高近红外（NIR）吸收率和高效的光热转换，FeOCl@PB@PDA@BPQDs@Mn纳米复合材料（NC）能够作为理想的光热治疗（PTT）的治疗诊断剂在体外和体内发挥作用。此外，FeOCl@PB@PDA@BPQDs@Mn NC还可以在不同的方法中用作多模态成像剂，例如磁共振（MR）、光声（PA）和超声（US）成像。在小鼠的肿瘤模型中，与任何单独的单一治疗方式相比，CDT、PDT和PTT与多模式成像组合实现了更显著的协同治疗结果。因此，本研究中的多功能纳米系统具有巨大的潜力，为有效的肿瘤治疗提供了令人满意的范例。
Herein, a novel tumor microenvironment (TME)-mediated nanotheranostics platform of iron oxychloride (FeOCl) nanorods coated with Prussian Blue (PB), polydopamine (PDA), black phosphorus quantum dots (BPQDs) and chelated with Mn2+was prepared. In the highly integrated nanoplatform (FeOCl@PB@PDA@BPQDs@Mn), FeOCl catalysts exhibit supreme efficiency to yield hydroxyl radicals (•OH) by H2O2decomposition for chemodynamic therapy (CDT). Moreover, the PB, FeOCl, and Mn2+have a catalase-like activity that catalyze H2O2to release of O2in the TME. Upon laser irradiation, the BPQDs transform O2to a singlet oxygen (1O2) to self-enhance photodynamic therapy (PDT). Additionally, as a result of the high near-infrared (NIR) absorption rate and efficient photothermal conversion of PB and PDA, FeOCl@PB@PDA@BPQDs@Mn nanocomposites (NCs) are capable to work as ideal theranostic agents for photothermal therapy (PTT)in vitroandin vivo. Furthermore, FeOCl@PB@PDA@BPQDs@Mn NCs can also serve as multimodal imaging agents in different methods, such as magnetic resonance (MR), photoacoustic (PA), and ultrasound (US) imaging. Among the tumor models of mice, CDT, PDT, and PTT that combined with multimodal imaging achieved a more significant synergistic therapeutic result compared to any single treatment modality alone. Therefore, the multifunctional nanosystem in this study possesses tremendous potential in providing a satisfying paradigm for effective tumor treatment.