Asymmetric Silica Nanoparticles with Tunable Head-Tail Structures Enhance Hemocompatibility and Maturation of Immune Cells
Asymmetric Silica Nanoparticles with Tunable Head-Tail Structures Enhance Hemocompatibility and Maturation of Immune Cells
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DOI：
10.1021/jacs.6b12622
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发表时间：
2017-05-10
影响因子：
15
通讯作者：
Yu, Chengzhong
中科院分区：
文献类型：
--
作者：
Abbaraju, Prasanna Lakshmi;Meka, Anand Kumar;Yu, Chengzhong
成功合成了具有可控头尾结构的不对称介孔二氧化硅纳米颗粒（MSN）。头部颗粒类型可调（实心或多孔），尾部具有树枝状大孔。尾部长度和尾部在头部颗粒上的覆盖范围是可调的。与具有固体结构的球形二氧化硅纳米颗粒（Stober球）或尾部完全覆盖的大孔对称MSN相比，不对称头尾MSN（HTMSN）由于红细胞膜变形减少和活性氧水平降低而表现出优异的血液相容性。此外，与 Stober 球相比，不对称 HTMSN 表现出更高水平的免疫细胞（包括树突状细胞和巨噬细胞）的摄取和体外成熟。这项研究提供了一个新的纳米载体家族，在疫苗开发和免疫治疗方面具有潜在的应用前景。
Asymmetric mesoporous silica nanoparticles (MSNs) with controllable head tail structures have been successfully synthesized. The head particle type is tunable (solid or porous), and the tail has dendritic large pores. The tail length and tail coverage on head particles are adjustable. Compared to spherical silica nanoparticles with a solid structure (Stober spheres) or large-pore symmetrical MSNs with fully covered tails, asymmetrical head tail MSNs (HTMSNs) show superior hemocompatibility due to reduced membrane deformation of red blood cells and decreased level of reactive oxygen species. Moreover, compared to Stober spheres, asymmetrical HTMSNs exhibit a higher level of uptake and in vitro maturation of immune cells including dendritic cells and macrophage. This study has provided a new family of nanocarriers with potential applications in vaccine development and immunotherapy.