Association of preexisting hypertension with the morality in patients with systolic heart failure in Taiwan: The TSOC-HFrEF registry.
Association of preexisting hypertension with the morality in patients with systolic heart failure in Taiwan: The TSOC-HFrEF registry.
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DOI：
10.1016/j.ihj.2018.01.009
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发表时间：
2018-09
影响因子：
1.5
通讯作者：
Lin WH
中科院分区：
文献类型：
--
作者：
Meng FC;Li YH;Lin GM;Lin CS;Yang SP;Lin WH
调查收缩性心力衰竭（HF）患者入院时既往存在的高血压与死亡率的关系。我们前瞻性地调查了台湾 1351 名心衰患者在平均 12 个月（范围：8 个月至 18 个月）的随访期内，既存高血压与死亡率的关系。对整个队列进行了多变量 Cox 回归分析，并按年龄进行了亚组分析。调整所有潜在危险因素后，在整个队列和年龄小于 65 岁的队列中，先前存在的高血压与心血管死亡率的关联显着降低（风险比 (HR)：0.53，95% 置信区间 (CI)：0.33-0.84，和 0.28，95% CI：0.11-0.67）。然而，这两组中与全因死亡率的相关性没有显着差异（HR：0.77，95% CI：0.54-1.09，和 0.59，95% CI：0.32-1.07）。此外，这些关联在 65 岁以上的患者中均不显着。对于亚洲收缩性心力衰竭患者，尤其是年龄较小的患者，既往高血压与心血管死亡率呈负相关。
To investigate the association of preexisting hypertension at admission with the mortality in patients with systolic heart failure (HF). We prospectively investigated the association of preexisting hypertension with the mortality among 1351 patients with HF in Taiwan during an average 12 months (range: 8 months–18 months) follow-up period. A multivariate cox regression analysis for the overall cohort and a subgroup analysis by age were performed. After adjustment for all potential risk factors, the associations of preexisting hypertension with cardiovascular mortality were significantly reduced in the overall cohort and those aged less than 65 years (hazard ratios (HR): 0.53, 95% confidence intervals (CI): 0.33–0.84, and 0.28, 95% CI: 0.11–0.67, respectively). However, the associations with all-cause mortality were not significantly different in these two groups (HR: 0.77, 95% CI: 0.54–1.09, and 0.59, 95% CI: 0.32–1.07, respectively). Furthermore, the associations were all nonsignificant in the patients aged older than 65 years. Preexisting hypertension have an inverse association with cardiovascular mortality in the Asian patients with systolic HF, particularly for those with younger ages.