An anticancer drug loading and release study to ternary GO-Fe3O4-PPy and Fe3O4 @PPy-NGQDs nanocomposites for photothermal chemotherapy
An anticancer drug loading and release study to ternary GO-Fe3O4-PPy and Fe3O4 @PPy-NGQDs nanocomposites for photothermal chemotherapy
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DOI：
10.1016/j.colsurfa.2021.127791
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发表时间：
2021-11-17
影响因子：
5.2
通讯作者：
Yildiz, Nuray
中科院分区：
文献类型：
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作者：
Atila Dincer, Ceren;Getiren, Bengu;Yildiz, Nuray
光热疗法（Photothermal Therapy，PTT）是一种针对传统癌症治疗方法而发展起来的新型治疗方法。在本研究中，氧化石墨烯-氧化铁-聚吡咯（GO-Fe 3 O 4-PPy）和氧化铁@聚吡咯氮掺杂的石墨烯量子点（Fe 3 O 4 @PPy-NGQDs）三元纳米复合材料具有上级的光热和磁性负载阿霉素（DOX）抗癌药物。通过紫外-可见光谱研究了DOX的负载和释放。在48小时结束时，GO-Fe 3 O 4-PPy/DOX和Fe 3 O 4 @ PPy-NGQD/DOX在pH 5.5和pH 7.4下的累积释放分别为99.55% +/- 0.20、48.87% +/- 0.20%和97.88% +/- 0.45、38.82% +/- 0.26。在短时间如4小时和8小时后，与没有NIR的药物释放相比，NIR触发的DOX释放显著增加。采用MTT法检测GO-Fe 3 O 4-PPy/DOX和Fe 3 O 4 @PPy-NGQDs/DOX载药纳米复合物对4 T1小鼠乳腺癌细胞的细胞毒作用。通过体外细胞毒性研究和共聚焦激光显微镜图像证明了具有NIR效应的DOX释放的增加。因此，多功能GO-Fe_3 O_4-PPy/DOX和Fe_3 O_4 @ PPy-NGQD/DOX纳米复合材料在光热化疗方面具有很大的应用潜力。
Photothermal therapy (PTT) is a new treatment method being developed against traditional cancer therapy methods. In this study, graphene oxide-iron oxide-polypyrrole (GO-Fe3O4-PPy) and iron oxide@polypyrrolenitrogen doped graphene quantum dots (Fe3O4 @PPy-NGQDs) ternary nanocomposites having superior photo thermal and magnetic properties were loaded with doxorubicin (DOX) anticancer drug. The loading and release of the DOX was investigated by UV-visible spectroscopy. At the end of 48 h, the cumulative release of DOX from GO-Fe3O4-PPy/DOX and Fe3O4 @PPy-NGQDs/DOX at pH 5.5 and pH 7.4 was obtained as 99.55% +/- 0.20, 48.87% +/- 0.20% and 97.88% +/- 0.45, 38.82% +/- 0.26, respectively. After a short period of time like 4 h and 8 h, NIR-triggered release of DOX was increased significantly compared to drug release without NIR. The cytotoxic effects on the 4T1 mouse breast cancer cells of GO-Fe3O4-PPy/DOX and Fe3O4 @PPy-NGQDs/DOX drug loaded nanocomposites were determined by MTT test. The increase of DOX release with NIR effect was demonstrated by both in-vitro cytotoxicity studies and confocal laser microscopy images. In summary, multifunctional GO-Fe3O4-PPy/DOX and Fe3O4 @PPy-NGQDs/DOX nanocomposites have great potential for photothermal chemotherapy.