PLATELET HYPERACTIVITY IN SICKLE-CELL DISEASE - A CONSEQUENCE OF HYPOSPLENISM
PLATELET HYPERACTIVITY IN SICKLE-CELL DISEASE - A CONSEQUENCE OF HYPOSPLENISM
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DOI：
10.1136/jcp.33.7.622
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发表时间：
1980-01-01
影响因子：
3.4
通讯作者：
STUART, J
中科院分区：
文献类型：
--
作者：
KENNY, MW;GEORGE, AJ;STUART, J
在16例无症状稳定状态的镰状细胞性贫血成人患者中29次测定血小板功能。与23名健康对照相比，ADP患者血小板数量和微聚集形成显著增加，聚集阈值较低。然而，在12例没有镰状细胞病的脾切除术患者中发现了类似的变化。因此，镰状细胞稳定状态的血小板过度活跃反映了先前自体脾切除术导致的年轻、代谢活跃的血小板循环人口的增加。
Platelet function was measured on 29 occasions in 16 adult patients in the asymptomatic steady state of sickle-cell anemia. There was a significant increase in platelet number and microaggregate formation, and a lower aggregation threshold with ADP, compared with 23 healthy controls. Similar changes were found, however, in 12 splenectomized patients without sickle-cell disease. The platelet hyperactivity of the sickle-cell steady state therefore reflects an increased circulating population of young, metabolically active platelets resulting from previous autosplenectomy.