The ancestry of the prolactin-releasing hormone precursor
The ancestry of the prolactin-releasing hormone precursor
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DOI：
10.1196/annals.1327.064
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Schiöth, HB
中科院分区：
文献类型：
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作者：
Lagerström, MC;Fredriksson, R;Schiöth, HB
催乳素释放激素（PRLH）与食物摄入有关，并在哺乳动物大脑的几个部位表达。肽前体（PRH）的起源尚不清楚，与其他已知的人类神经肽序列相似的唯一特征是C末端RF基序，也存在于神经肽FF和神经肽RF酰胺相关肽家族（RFRP）中。我们最近在鸡中发现了PRH和密切相关的前体GRF酰胺的序列，揭示了PRH的祖先。
The prolactin-releasing hormone (PRLH) is implicated in food intake and is expressed in several parts of the mammalian brain. The origin of the peptide precursor (PRH) has been unclear, and the only feature resembling other known human neuropeptide sequences is the C-terminal RF-motif, also present in the neuropeptide FF and the neuropeptide RF amide-related peptide families (RFRP). We have recently found sequences of PRH and the closely related precursor GRF amide in chicken, shedding light on the PRH ancestry.