Antitussive arabinogalactan of Andrographis paniculata demonstrates synergistic effect with andrographolide.
Antitussive arabinogalactan of Andrographis paniculata demonstrates synergistic effect with andrographolide.
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DOI：
10.1016/j.ijbiomac.2014.05.030
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发表时间：
2014-08
影响因子：
8.2
通讯作者：
G. Nosáľová;S. K. Majee;K. Ghosh;Washim Raja;U. R. Chatterjee;L. Jurecek;B. Ray
中科院分区：
文献类型：
--
作者：
G. Nosáľová;S. K. Majee;K. Ghosh;Washim Raja;U. R. Chatterjee;L. Jurecek;B. Ray
Traditional Indian medicines have been used in humans for thousands of years. While the link to a particular indication has been established in man, the active principle of the formulations often remains unknown. In this study, we aim to investigate the structural features and antitussive activity of fractions fromAndrographis paniculataleaves.In vivoinvestigations of water extract (WE), and both ethanol-soluble (WES) and precipitated (WEP) fractions from WE on the citric-acid induced cough efforts and airways smooth muscle reactivity in guinea pigs were performed. Chemical, chromatographic and spectroscopic analysis revealed the existence of a highly branched pectic arabinogalactan (109 kDa) in WEPand andrographolide in WES. WEPshowed significant antitussive activity while the potencies of WE and WESare even higher. Neither WE nor WESsignificantly alter specific airway smooth muscle reactivity. Remarkably, the antitussive activity of arabinogalactan could be increased by synergistic action with andrographolide. Finally, traditional aqueous extraction method provides an arabinogalactan fromA. paniculata, which stimulate biological response but without addiction.
