Linkage disequilibrium and genetic variances under mutation-selection balance.
Linkage disequilibrium and genetic variances under mutation-selection balance.
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突变选择平衡下的连锁不平衡和遗传方差。
DOI：
10.1093/genetics/121.4.857
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发表时间：
1989
期刊：
影响因子：
3.3
通讯作者：
Hastings,A
中科院分区：
文献类型：
--
作者：
Hastings,A
我使用两个基因座以及诱导或边缘系统的结果确定连锁不平衡对遗传方差的贡献。该分析允许上位性和显性，但假设突变相对于选择较弱。如果配子突变率除以成对重组率的调和平均值远小于 1，则遗传方差的连锁不平衡成分对于未连锁位点来说并不重要。对于紧密连锁的基因座，如果配子突变率除以（诱导的）每个基因座选择远小于一，则连锁不平衡并不重要。
I determine the contribution of linkage disequilibrium to genetic variances using results for two loci and for induced or marginal systems. The analysis allows epistasis and dominance, but assumes that mutation is weak relative to selection. The linkage disequilibrium component of genetic variance is shown to be unimportant for unlinked loci if the gametic mutation rate divided by the harmonic mean of the pairwise recombination rates is much less than one. For tightly linked loci, linkage disequilibrium is unimportant if the gametic mutation rate divided by the (induced) per locus selection is much less than one.