Behavioral and physiological adaptation to repeated chair restraint in rhesus macaques
Behavioral and physiological adaptation to repeated chair restraint in rhesus macaques
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DOI：
10.1016/j.physbeh.2004.02.031
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发表时间：
2004-09-15
影响因子：
2.9
通讯作者：
Mason, WA
中科院分区：
文献类型：
--
作者：
Ruys, JD;Mendoza, SP;Mason, WA
在与非人类灵长类动物密切合作时，身体约束是一种常用的方法。非人类灵长类动物在学习约束过程中表现出快速的行为变化，这些变化反映了对该过程的行为和生理习惯。本研究检测了大量成年雄性恒河猴对重复身体约束的行为和肾上腺皮质反应。在连续7天的约束中，受试者表现出行为躁动和皮质醇浓度的下降。肾上腺皮质反应性的变化也与地塞米松敏感性的增加和清晨基底皮质醇分泌的变化相一致。6个月后，受试者被限制了一次，虽然行为躁动的减少仍然存在，但肾上腺皮质反应性的大部分变化不再存在。这些数据表明，行为不一定是潜在生理过程的指标，反复约束下丘脑-垂体-肾上腺（HPA）活性的降低是由于对高糖皮质激素浓度的生理适应，而不是对约束程序的心理习惯。(C) 2004爱思唯尔公司版权所有。
Physical restraint is a commonly used procedure when working closely with nonhuman primates. Nonhuman primates show rapid behavioral changes when learning the restraint procedure, and these changes have been taken to reflect behavioral and physiological habituation to the procedure. This study examined the behavioral and adrenocortical responses to repeated physical restraint in a large sample of adult male rhesus monkeys. Subjects showed a decline in behavioral agitation and cortisol concentrations across seven consecutive days of restraint. The changes in adrenocortical responsiveness were also coincident with an increased sensitivity to dexamethasone and a change in early morning basal cortisol secretion. The subjects were restrained for a single session 6 months later, and while the reduction in behavioral agitation was still present, the majority of changes in adrenocortical responsiveness were no longer present. These data show that behavior is not necessarily an indicator of underlying physiological processes and that the reduction of hypothalamic-pituitary-adrenal (HPA) activity with repeated restraint is due to physiological adaptation to high glucocorticoid concentrations and not to psychological habituation to the restraint procedures. (C) 2004 Elsevier Inc. All rights reserved.