Plasma & urinary catecholamines & urinary vanillylmandelic acid levels in patients with generalized vitiligo.
Plasma & urinary catecholamines & urinary vanillylmandelic acid levels in patients with generalized vitiligo.
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DOI：
10.4103/ijmr.ijmr_657_16
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Gupta S
中科院分区：
文献类型：
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作者：
Basnet B;Bhushan A;Khan R;Kumar G;Sharma VK;Sharma A;Gupta S
白癜风是一种获得性皮肤病，其特征是皮肤的色素脱失区域。白癜风的发病机制可能与皮损黑素细胞微环境中植物神经末梢释放的儿茶酚胺增加有关。儿茶酚胺的水平被认为与疾病的发作或恶化有关。因此，在这项研究中，评价了儿茶酚胺在绘制白癜风患者接受黑素细胞转移的疾病稳定性和结果中的作用。本文采用酶联免疫吸附法（ELISA）测定了45例白癜风患者（30例白癜风患者和15例健康对照者）循环血和尿中儿茶酚胺（CA）和香草扁桃酸（VMA）的含量。与健康对照组相比，观察到血浆和尿儿茶酚胺沿着VMA显著增加。当分别在反应者和非反应者中分析干预前和干预后的水平时，只有多巴胺在尿液中显示出显著下降，血浆和尿液中的其余分子显示出非显著下降，除了VMA显示出不显著的增加。血浆/尿肾上腺素和血浆多巴胺水平不能作为泛发性白癜风患者疾病稳定性或自体黑素细胞转移成功结局的生物标志物。然而，多巴胺（尿）可能有助于确定泛发性白癜风患者接受黑素细胞转移的稳定性。需要对大样本患者进行进一步研究以证实我们的发现。
Vitiligo is an acquired skin disease characterized by depigmented areas of the skin. Increased release of catecholamines from autonomic nerve endings in microenvironment of melanocytes in affected skin might be involved in the aetiopathogenesis of vitiligo. Levels of catecholamines are considered as being related to onset or worsening of the disease. Therefore, in this study, the role of catecholamines was evaluated in mapping disease stability and outcome of vitiligo patients undergoing melanocyte transfer. In this study, circulatory and urinary levels of catecholamine (CA) and vanillylmandelic acid (VMA) were determined in 45 individuals (30 vitiligo patients and 15 healthy controls) using ELISA. A significant increase for plasma and urinary catecholamines along with VMA was observed as compared to healthy controls. When the pre- and post-intervention levels were analyzed in responders and non-responders, respectively, only dopamine showed significant decline in urine, rest of the molecules in plasma as well as urine showed non-significant decline except VMA which showed insignificant increase. Levels of plasma/urinary epinephrine, and plasma dopamine, could not be established as biomarkers for disease stability or successful outcome of autologous melanocyte transfer in generalized vitiligo patients. However, dopamine (urine) might be of help in determining the stability in patients with generalized vitiligo undergoing melanocyte transfer. Further studies need to be done on a large sample of patients to confirm our findings.