Optical Regulation of Protein Adsorption and Cell Adhesion by Photoresponsive GaN Nanowires
Optical Regulation of Protein Adsorption and Cell Adhesion by Photoresponsive GaN Nanowires
复制标题
光响应GaN纳米线对蛋白质吸附和细胞粘附的光学调节
DOI：
10.1021/am403070g
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发表时间：
2013-10-09
影响因子：
9.5
通讯作者：
Wang, Chen
中科院分区：
文献类型：
--
作者：
Li, Jingying;Han, Qiusen;Wang, Chen
由于纳米线在细胞培养工程和药物输送等方面的潜在应用，使得纳米线与活细胞的连接引起了越来越多的关注。我们报告的可行性，使用光响应半导体氮化镓（GaN）纳米线（NW）的生物分子和细胞的行为在纳米/生物界面的调节。GaN纳米线是通过一种简单的化学气相沉积方法制备的。通过紫外光照射实现了纳米线的超疏水性到超亲水性的转变。牛血清白蛋白的吸附可以调制光响应GaN纳米线。还观察到可调的细胞脱离和粘附。NW表面负责调节蛋白质吸附和细胞粘附的机制进行了讨论。GaN纳米线对蛋白质吸附和细胞粘附的调制效应的这些观察可以提供一种新的方法来调节生物分子和细胞在纳米/生物界面处的行为，这在开发用于细胞培养工程、生物分离和诊断的高性能半导体纳米线生物医学器件中可能具有相当重要的意义。
Interfacing nanowires with living cells is attracting more and more interest due to the potential applications, such as cell culture engineering and drug delivery. We report on the feasibility of using photoresponsive semiconductor gallium nitride (GaN) nanowires (NWs) for regulating the behaviors of biomolecules and cells at the nano/biointerface. The GaN NWs have been fabricated by a facile chemical vapor deposition method. The superhydrophobicity to superhydrophilicity transition of the NWs is achieved by UV illumination. Bovine serum albumin adsorption could be modulated by photoresponsive GaN NWs. Tunable cell detachment and adhesion are also observed. The mechanism of the NW surface responsible for modulating both of protein adsorption and cell adhesion is discussed. These observations of the modulation effects on protein adsorption and cell adhesion by GaN NWs could provide a novel approach toward the regulation of the behaviors of biomolecules and cells at the nano/biointerface, which may be of considerable importance in the development of high-performance semiconductor nanowire-based biomedical devices for cell culture engineering, bioseparation, and diagnostics.