Abnormal baseline brain activity in suicidal and non-suicidal patients with major depressive disorder
Abnormal baseline brain activity in suicidal and non-suicidal patients with major depressive disorder
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患有重度抑郁症的自杀和非自杀患者的基线大脑活动异常
DOI：
10.1016/j.neulet.2012.11.032
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发表时间：
2013-02-08
影响因子：
2.5
通讯作者：
Dong, Jie
中科院分区：
文献类型：
--
作者：
Fan, Tingting;Wu, Xia;Dong, Jie
先前的研究表明，自杀企图与严重抑郁障碍(MDD)密切相关，而试图自杀的MDD患者一生中自杀死亡的风险很高。我们的目的是探索有和没有自杀未遂病史的MDD患者静息状态脑活动的差异。我们使用一种名为低频波动幅度(ALFF)的方法来实现这一点。ALF反映了特定大脑区域的局部特性，并提供了有关受损区域的直接信息。这种方法不同于功能连接。在这项研究中，我们比较了三组：有和没有自杀未遂史的MDD患者，以及正常对照组(NC)。主要结果是自杀未遂者右侧颞上回(r-STG)较非自杀患者(NSU)和正常对照组(NC)的ALF值增加。此外，与自杀未遂者(SU)和正常对照组相比，NSU使右脑腹侧内侧额回(r-vMFG)的ALFF增加。与NC相比，NSU和SU均增加了左侧扣带回前部(L-ACC)和右侧海马旁回(r-PG)的ALF值，降低了左侧枕中回(L-MOG)和左角回(L-AG)的ALF值。(C)2012爱思唯尔爱尔兰有限公司。保留所有权利。
Previous studies have shown that suicide attempts are strongly associated with major depressive disorder (MDD), and MDD patients who attempt suicide have a high risk of death by suicide throughout their lifetimes. We aimed to explore the differences in resting-state brain activity in MDD patients with and without histories of suicide attempt. We accomplished this using an approach named amplitude of low-frequency fluctuation (ALFF). ALFF reflects the local properties of specific brain regions and provides direct information about impaired regions. This approach differs from functional connectivity. In this study, we compared three groups: MDD patients with and without histories of suicide attempt, and normal controls (NC). The main result is that suicide attempters had increased ALFF in the right superior temporal gyrus (r-STG) relative to both non-suicidal patients (NSU) and NC. In addition, NSU had increased ALFF in the right ventral medial frontal gyrus (r-vMFG) relative to both suicide attempters (SU) and NC. Finally, both NSU and SU had increased ALFF in the left anterior cingulated cortex (l-ACC) and right parahippocampal gyrus (r-PG) and decreased ALFF in the left middle occipital gyrus (l-MOG) and left angular gyms (l-AG) relative to NC. (C) 2012 Elsevier Ireland Ltd. All rights reserved.