Single-Dose T3 Administration: Kinetics and Effects on Biochemical and Physiological Parameters
Single-Dose T3 Administration: Kinetics and Effects on Biochemical and Physiological Parameters
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DOI：
10.1097/ftd.0000000000000113
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发表时间：
2015-02-01
影响因子：
2.5
通讯作者：
Latham, Keith R.
中科院分区：
文献类型：
--
作者：
Jonklaas, Jacqueline;Burman, Kenneth D.;Latham, Keith R.
背景：在使用单剂量碘甲状腺原氨酸后，促甲状腺激素（TSH）、甲状腺激素和生命体征的变化通常只记录了24小时，我们记录了这些参数超过96小时。方法：对12名甲状腺功能正常的健康受试者，在给予50 mcg碘甲状腺原氨酸4天后采集血样。测定总三碘甲状腺原氨酸和游离三碘甲状腺原氨酸、游离甲状腺素和总甲状腺素以及TSH的浓度。记录生命体征。结果：三碘甲状腺原氨酸浓度在给药后2.5小时达到峰值。给药后5小时心率（HR）升高，随后达到高于基线的值（P = 0.009）。TSH浓度的抑制开始于2小时。12小时的最低点TSH值与基线值有显著差异（P < 0.001），并在2-3天内保持低于基线值。结论：单剂量的碘甲状腺原氨酸有短期和长期的影响。三碘甲状腺原氨酸的血清浓度与其对心脏和垂体的影响之间明显存在不同的滞后时间。血清三碘甲状腺原氨酸浓度在数小时内升高，随后HR升高。HR升高是短暂的，随后TSH浓度降低。TSH的抑制是延迟的，但更持久。因此，单剂量的碘甲状腺原氨酸仅产生血清三碘甲状腺原氨酸水平的短暂增加和HR的短暂增加，即可实现24小时以上持续的TSH降低。
Background: As changes in thyroid stimulating hormone (TSH), thyroid hormones, and vital signs after administration of a single dose of liothyronine have typically only been documented for 24 hours, we documented these parameters more than 96 hours.Methods: Blood samples were obtained for 4 days after administration of 50-mcg liothyronine to 12 healthy euthyroid participants. Concentrations of total and free triiodothyronine, free and total thyroxine, and TSH were measured. Vital signs were documented.Results: Triiodothyronine concentrations peaked at 2.5 hours after liothyronine administration. Heart rate (HR) increased by 5 hours after liothyronine administration, subsequently reaching a value higher than baseline (P = 0.009). Suppression of TSH concentrations began at 2 hours. The nadir TSH value at 12 hours was significantly different from baseline (P < 0.001) and remained lower than the baseline value for 2-3 days.Conclusions: A single dose of liothyronine has both short-term and long-term effects. There is clearly a different lag time between the serum concentrations of triiodothyronine and its effects on the heart and pituitary, respectively. The increase in serum triiodothyronine concentration occurred within hours and was then followed by an increase in HR. The increased HR was transient and was followed by a reduction in TSH concentration. The suppression of TSH was delayed but was more sustained. Thus, sustained TSH reduction beyond 24 hours was achieved by a single dose of liothyronine that produced only brief increases in serum triiodothyronine levels and transient increases in HR.