Thalamocortical conduction times and stimulus-evoked responses in the rat whisker-to-barrel system.
Thalamocortical conduction times and stimulus-evoked responses in the rat whisker-to-barrel system.
复制标题
大鼠胡须到桶系统中的丘脑皮质传导时间和刺激诱发的反应。
DOI：
10.1152/jn.00800.2007
复制
发表时间：
2007
影响因子：
2.5
通讯作者：
Bruno,RandyM
中科院分区：
文献类型：
--
作者：
Simons,DanielJ;Carvell,GeorgeE;Kyriazi,HaroldT;Bruno,RandyM
对啮齿动物胡须系统的研究表明，体感皮层回路以毫秒级的时间尺度运作，以转换来自丘脑的感觉传入信号。我们测量了48个丘脑皮层（TC）神经元的轴突传导时间和胡须诱发反应的大鼠胡须到桶路径。传导时间来自尖峰触发的平均值的局部场电位诱发的第4层皮质须相关桶的自发放电的个别地形对齐的神经元在腹后内侧丘脑。传导时间变化四倍，从0.31到1.34毫秒，更快的TC神经元进行反应更早，更强大的控制胡须偏转。早期到达的高反应TC输入，被认为优先接触抑制性桶神经元，可以启动皮层网络，使其对晚到的信号更具选择性。
Studies of the rodent whisker system indicate that somatosensory cortical circuitry operates at a millisecond timescale to transform sensory afferent signals from the thalamus. We measured axon conduction times and whisker-evoked responses of 48 thalamocortical (TC) neurons in the rat whisker-to-barrel pathway. Conduction times were derived from spike-triggered averages of local field potentials evoked in layer 4 cortical whisker-related barrels by the spontaneous firing of individual topographically aligned neurons in the ventral posterior medial thalamus. Conduction times varied fourfold, from 0.31 to 1.34 ms, and faster conducting TC neurons responded earlier and more robustly to controlled whisker deflections. Early arrival of highly responsive TC inputs, thought to contact inhibitory barrel neurons preferentially, could prime the cortical network, rendering it more selective for later-arriving signals.