Bioactive furanocoumarins from the stems and leaves of Clausena hainanensis
Bioactive furanocoumarins from the stems and leaves of Clausena hainanensis
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海南黄皮茎叶中的生物活性呋喃香豆素
DOI：
10.1080/14786419.2017.1367786
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发表时间：
2018
影响因子：
2.2
通讯作者：
Liu Yan-Ping
中科院分区：
文献类型：
--
作者：
Ma Yan-Lei;Zhang Chao;Zhao Wan-Hui;Shi Shi;He Dan-Nv;Zhang Pan;Liu Xiao-Hong;Han Ting-Ting;Fu Yan-Hui;Liu Yan-Ping
从海南克劳塞纳 (Clausena hainanensis) 的茎和叶中分离出一种新的呋喃香豆素 Clauhainanin A (1) 以及七种已知的呋喃香豆素 (2-8)。通过广泛的光谱方法阐明了 1 的结构，并通过与文献报道的数据比较来鉴定已知化合物。所有已知化合物 (2–8) 均从 C 中分离出来。海南海南第一次。在体外评估了所有分离的化合物对五种人类癌细胞系的细胞毒性：HL-60、SMMC-7721、A-549、MCF-7 和 SW480。化合物 1–8 表现出显着的抑制作用，IC50 值范围为 1.36 至 18.96 μM。
A new furanocoumarin, clauhainanin A (1), together with seven known furanocoumarins (2–8), were isolated from the stems and leaves ofClausena hainanensis. The structure of1was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All known compounds (2–8) were isolated fromC. hainanensisfor the first time. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480in vitro. Compounds1–8exhibited significant inhibitory effects with IC50values ranging from 1.36 to 18.96 μM.