Buying time: FASCIATA1 deficiency rescues wee1 plants from replication stress by delaying mitosis.
Buying time: FASCIATA1 deficiency rescues wee1 plants from replication stress by delaying mitosis.
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DOI：
10.1093/plphys/kiab256
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发表时间：
2021-08-03
期刊：
影响因子：
7.4
通讯作者：
Tulin F
中科院分区：
文献类型：
--
作者：
Tulin F
细胞有非凡的能力忠实地复制和分离基因组，即使复制受到各种类型的DNA损伤的挑战。染色体分离的保真度依赖于DNA损伤反应(DDR)，这是一个检查点系统，激活DNA修复基因，阻止细胞周期进程，直到损伤修复。检验点蛋白WEE1已成为植物DDR的核心成分，主要来自对拟南芥(Arabiopsis Thaliana)的研究。在本期《植物生理学》中，Eekhout等人。研究WEE1依赖和非依赖的信号通路如何在应激状态下促进DNA复制的完成。在植物中，就像在其他真核生物中一样，两个密切相关的传感器蛋白--共济失调毛细血管扩张突变(ATM)和ATM与Rad3相关(ATR)--启动DNA损伤信号(图1)。ATM负责处理双链断裂，这是一种特别危险的DNA损伤类型，必须在细胞进入有丝分裂之前修复。更广泛地需要ATR来检测延伸的单链DNA，这是S阶段复制应激的常见结果。在ATM/ATR下游，这两条通路会聚在伽马反应的主要规则抑制因子1(SOG1)上，SOG1是ATM的直接底物，负责广泛的DNA修复和细胞周期基因的转录激活(Ogita等人，2018年)。SOG1的失活通常会阻止ATM和ATR依赖的信号转导(图1)，从而对DNA损伤耐受性和基因组稳定性造成严重后果(Yoshiyama等人，2009年)。
Cells have a remarkable ability to faithfully duplicate and segregate the genome, even when replication is challenged by various types of DNA damage. The fidelity of chromosome segregation relies on the DNA damage response (DDR), a checkpoint system that activates DNA repair genes and blocks cell cycle progression until the damage is repaired. The checkpoint kinase WEE1 has emerged as a core component in the plant DDR, mainly from studies in Arabidopsis (Arabidopsis thaliana). In this issue of Plant Physiology, Eekhout et al. investigate how both WEE1-dependent and-independent signaling pathways contribute to completion of DNA replication in the presence of stress. In plants, as in other eukaryotes, two closely related sensor kinases, ATAXIA TELANGIECTASIA MUTATED (ATM) and ATM AND RAD3-RELATED (ATR), initiate DNA damage signaling (Figure 1). ATM is responsible for processing doublestranded breaks, a particularly dangerous type of DNA damage that must be repaired before the cell enters mitosis. ATR is more broadly required for sensing extended tracts of single-stranded DNA, a common consequence of replication stress during S phase. Downstream of ATM/ATR, the two pathways converge on the master regular SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1), which is a direct substrate of ATM and responsible for transcriptional activation of a broad range of DNA repair and cell cycle genes (Ogita et al., 2018). Inactivation of SOG1 generally blocks both ATM-and ATR-dependent signaling (Figure 1) with severe consequences for DNA damage tolerance and genome stability (Yoshiyama et al., 2009).
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影响因子：
7.4
作者：
Eekhout, Thomas;Dvorackova, Martina;De Veylder, Lieven
通讯作者：
De Veylder, Lieven
影响因子：
11.6
作者：
Kalhorzadeh, Pooneh;Hu, Zhubing;De Veylder, Lieven
通讯作者：
De Veylder, Lieven
影响因子：
11.6
作者：
Cools, Toon;Iantcheva, Anelia;De Veylder, Lieven
通讯作者：
De Veylder, Lieven
影响因子：
7.2
作者：
Ogita, Nobuo;Okushima, Yoko;Umeda, Masaaki
通讯作者：
Umeda, Masaaki
影响因子：
56.9
作者：
WEINERT, TA;HARTWELL, LH
通讯作者：
HARTWELL, LH