Adoptive immunotherapy of leukemia in the rat, without graft-VS-host complications.
Adoptive immunotherapy of leukemia in the rat, without graft-VS-host complications.
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大鼠白血病的过继免疫治疗，无移植物抗宿主并发症。
DOI：
10.4049/jimmunol.123.4.1478
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发表时间：
1979
影响因子：
4.4
通讯作者：
Bruce Roser
中科院分区：
文献类型：
--
作者：
Owen Westcott;Susan Dorsch;Bruce Roser
用来自对白血病或PVG淋巴细胞致敏的AUG大鼠的大量淋巴细胞接种物治疗患有可移植T细胞白血病的PVG大鼠。 AUG 和 PVG 具有相同的 Ag-B 抗原，但在较小的基因座上有所不同，包括 Pta 基因座，其编码仅在外周 T 淋巴细胞上表达的分化抗原。使用对 PVG 白血病或正常 PVG 细胞免疫的 AUG 细胞进行治疗，导致白血病大鼠的存活时间延长、严重但短暂的白细胞减少以及白血病细胞从淋巴组织中消失的时间延长。然而，所有接受治疗的动物最终都因硬组织和软组织中大量、离散的白血病细胞沉积而死亡。尽管故意使宿主细胞和供体细胞的次要移植抗原不匹配，但在治疗的大鼠中没有观察到 GVH 症状的证据。这被解释为将过继免疫反应引导至受限分布的抗原，即针对白细胞而非体细胞。
PVG rats bearing a transplantable T cell leukemia were treated with large inocula of lymphoid cells from AUG rats sensitized either against the leukemia or against PVG lymphocytes. AUG and PVG bear identical Ag-B antigens but differ at minor loci, including the Pta loci, which code for differentiation antigens expressed only on peripheral T lymphocytes. Treatment with AUG cells immune to either the PVG leukemia or normal PVG cells resulted in prolonged survival of leukemic rats, a profound but ephemeral leukopenia and prolonged disappearance of leukemic cells from lymphoid tissue. All treated animals, however, eventually died with large, discrete deposits of leukemic cells in both hard and soft tissues. Despite the deliberate mismatching of host and donor cells for minor transplanation antigens, no evidence of GVH symptoms was observed in treated rats. This was interpreted as a result of directing the adoptive immune response to antigens of restricted distribution, i.e., on leukocytes and not on somatic cells.