Comparison of degradation behavior and the associated bone response of ZK60 and PLLA in vivo
Comparison of degradation behavior and the associated bone response of ZK60 and PLLA in vivo
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ZK60 和 PLLA 体内降解行为及相关骨反应的比较
DOI：
10.1002/jbm.a.34795
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发表时间：
2014-05-01
影响因子：
4.9
通讯作者：
Wang, Yan
中科院分区：
文献类型：
--
作者：
Qi, Zheng-Rong;Zhang, Qiang;Wang, Yan
本研究的目的是调查是否ZK 60，挤压镁合金，在体内反应与适当的主机响应，并调查微弧氧化处理如何影响这种在体内的腐蚀行为。从挤压ZK 60加工12个圆柱体，其中6个圆柱体用MAO处理，6个未处理;聚-l-乳酸销用作对照以比较生物相容性。将这些圆柱体从内侧髁沿经上髁轴沿着植入小鼠的右侧股骨远端。使用微计算机断层扫描以非破坏性方式定量分析体内腐蚀，并根据残留植入物的体积测量值计算腐蚀速率。通过临床观察和血液生化分析，了解植入后大鼠的生理反应。种植体周围软组织的组织学分析用于评估与种植体相关的骨反应。所得结果清楚地表明，未经处理的ZK 60合金在体内表现出高降解速率，并且MAO处理在保护植入物免受进一步腐蚀方面具有显著但不令人满意的效果。与PLLA相比，ZK 60合金具有良好的骨传导性和骨诱导性，并根据生化指标，具有良好的体内生物相容性。(c)2013 Wiley Periodicals，Inc. J Biomed Mater Res Part A：102A：1255-1263，2014.
The aim of this study was to investigate whether ZK60, an extruded magnesium alloy, reacts in vivo with an appropriate host response, and to investigate how microarc oxidation treatment influences this in vivo corrosion behavior. Twelve cylinders were machined from as-extruded ZK60, with six cylinders treated with MAO and six left untreated; poly-l-lactic acid pins were used as a control to compare biocompatibility. These cylinders were implanted into the right distal femur of mice along the transepicondylar axis from the medial condyle. Microcomputerized tomography was used to quantitatively analyze corrosion in a nondestructive manner in vivo and the corrosion rate was calculated based on the volume measurements of the residual implants. The physiological response of the rats postimplantation was obtained by clinical observation and blood biochemical analysis. Histological analyses of the soft tissue around the implants were used to assess bone response in relation to the implants. The results obtained clearly indicate that the untreated ZK60 alloy showed high degradation rates in vivo, and that MAO treatment had a significant but unsatisfying effect on protecting the implant from further corrosion. Compared with PLLA, the ZK60 alloy showed good osteoconductivity and osteoinductivity, and, according to biochemical indicators, had good biocompatibility in vivo. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1255-1263, 2014.