Aldehydes and Ketones Formation: Copper-Catalyzed Aerobic Oxidative Decarboxylation of Phenylacetic Acids and α-Hydroxyphenylacetic Acids
Aldehydes and Ketones Formation: Copper-Catalyzed Aerobic Oxidative Decarboxylation of Phenylacetic Acids and α-Hydroxyphenylacetic Acids
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DOI：
10.1021/jo402778p
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发表时间：
2014-02-21
影响因子：
3.6
通讯作者：
Song, Qiuling
中科院分区：
文献类型：
--
作者：
Feng, Qiang;Song, Qiuling
以铜为催化剂，苯乙酸和α-羟基苯乙酸为原料合成了芳香醛或芳香酮。该反应以分子氧为唯一的末端氧化剂，以一锅法结合了脱羧基、氧活化和C-H键氧化步骤。该反应代表了一种新的SP(3)杂化碳的脱羧基反应，并使用了一种苄基羧酸作为羰基化合物的来源。
Aromatic aldehydes or ketones from copper catalyzed aerobic oxidative decarboxylation of phenylacetic acids and alpha-hydroxyphenylacetic acids have been synthesized. This reaction combined decarboxylation, dioxygen activation, and C-H bond oxidation steps in a one-pot protocol with molecular oxygen as the sole terminal oxidant. This reaction represents a novel decarboxylation of an sp(3)-hybridized carbon and the use of a benzylic carboxylic acid as a source of carbonyl compounds.