Nickel release after implantation of the amplatzer occluder
Nickel release after implantation of the amplatzer occluder
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DOI：
10.1067/mhj.2003.7
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发表时间：
2003-04-01
影响因子：
4.8
通讯作者：
Meyer, J
中科院分区：
文献类型：
--
作者：
Ries, MW;Kampmann, C;Meyer, J
房间隔缺损经导管封堵术是一种较心内直视手术创伤小的新技术。近年来，卵圆孔未闭患者持续潜在的反常栓塞也成为介入封堵器械的候选者。Amplatzer间隔封堵器是最流行的封堵器之一，与许多其他封堵器一样，它由镍钛合金制成。镍钛诺基合金广泛应用于医疗产品，例如骨科和骨科。然而，镍钛合金（含55%镍）的临床应用仍存在争议，因为人们担心其生物相容性。因此，我们研究了全身镍释放植入后的Amplatzer occluder.Methods和结果在67例无镍敏感的历史，血液样本采集前24小时和24小时，1，3，12个月后，封堵器植入。用原子吸收光谱法测定血清镍浓度，
Background Transcatheter closure of atrial septal defects is a new and less traumatic technique than open heart surgery. In recent years, patients with a patent foramen ovale sustaining potential paradoxical embolism have also, become candidates for interventional closure devices. One of the more popular occluding devices is the Amplatzer septal occluder, which, like many other occluders, is made of nitinol. Nitinol-based alloys are widely used in medical products, for example, in orthopedics and orthodontics. However, the clinical use of nitinol, which contains 55% nickel, is still controversial because of concerns about its biocompatibility. Therefore, we examined the systemic nickel release after implantation of the Amplatzer occluder.Methods and Results In 67 patients with no history of nickel sensitivity, blood samples were taken 24 hours before and 24 hours, 1, 3, and 12 months after occluder implantation. Nickel serum concentrations were measured by atomic absorption spectrometry; a value of