Expression of FGFs during early mouse tongue development.
Expression of FGFs during early mouse tongue development.
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DOI：
10.1016/j.gep.2015.12.003
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Klein OD
中科院分区：
文献类型：
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作者：
Du W;Prochazka J;Prochazkova M;Klein OD
成纤维细胞生长因子 (FGF) 是最大的生长因子家族之一，已知该家族中的几种配体和受体在舌头发育过程中发挥关键作用。为了为研究FGF在舌头形成过程中的作用提供全面的基础，我们通过定量PCR测量了转录物水平，并通过原位杂交绘制了小鼠胚胎(E) 11.5至E14.5天舌头发育过程中所有22个Fgf的表达模式。在此期间，Fgf5、Fgf6、Fgf7、Fgf9、Fgf10、Fgf13、Fgf15、Fgf16和Fgf18均在间质中以不同强度表达，而Fgf1和Fgf2在上皮和间质中均表达。我们的结果表明 FGF 信号在多个阶段调节舌头发育。
The fibroblast growth factors (FGFs) constitute one of the largest growth factor families, and several ligands and receptors in this family are known to play critical roles during tongue development. In order to provide a comprehensive foundation for research into the role of FGFs during the process of tongue formation, we measured the transcript levels by quantitative PCR and mapped the expression patterns by in situ hybridization of all 22 Fgfs during mouse tongue development between embryonic days (E) 11.5 and E14.5. During this period, Fgf5, Fgf6, Fgf7, Fgf9, Fgf10, Fgf13, Fgf15, Fgf16 and Fgf18 could all be detected with various intensities in the mesenchyme, whereas Fgf1 and Fgf2 were expressed in both the epithelium and the mesenchyme. Our results indicate that FGF signaling regulates tongue development at multiple stages.