Lithium transport in human red blood cells: genetic and clinical aspects.
Lithium transport in human red blood cells: genetic and clinical aspects.
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人类红细胞中的锂转运：遗传和临床方面。
DOI：
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发表时间：
1979
影响因子：
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通讯作者：
Daniel C. Tosteson
中科院分区：
文献类型：
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作者：
G N Pandey;E. Dorus;John M. Davis;Daniel C. Tosteson
在接受碳酸锂治疗的情感障碍患者中，红细胞中的锂浓度低于血浆中的锂浓度，表明离子从细胞中主动转运（类似于Na +流出）。已经观察到Li+比率（定义为细胞内Li浓度/细胞外Li +浓度）的稳态体内分布的广泛变化，其在一定程度上受遗传控制。1-3人们已经研究了这个比率与精神病诊断、锂治疗的短期和长期反应以及Li +给药副作用的关系。初步证据表明，双相情感障碍患者体内Li +比率高于正常对照组。[4]对锂治疗有反应的患者比无反应者Li +比率更高的发现5-7尚未得到所有研究人员的证实。8-9 Li +治疗的副作用可能与细胞内Li +浓度或细胞内Li+浓度相关性更高。
In patients with affective disorders who are being treated with lithium carbonate, lithium concentration is lower in RBCs than in plasma, suggesting an active transport of the ion from the cells (similar to Na + efflux). Wide variations have been observed in the steady state in vivo distribution of Li+ ratio (defined as intracellular Li concentration/extracellular Li + concentration), which is under genetic control to some degree. 1-3 The relationship of this ratio to psychiatric diagnosis, to short- and long-term response to lithium therapy, and to the side effects of Li + administration has been studied. Preliminary evidence shows that patients with bipolar illness have higher Li + ratios in vivo than normal controls. 4 The finding that patients who respond to lithium therapy have higher Li + ratios than nonresponders 5-7 has not been confirmed by all investigators. 8-9 Side effects of Li + therapy may be more highly correlated with intracellular Li + concentrations or the Li+