Chromosome 17q12 variants contribute to risk of early-onset prostate cancer
Chromosome 17q12 variants contribute to risk of early-onset prostate cancer
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DOI：
10.1158/0008-5472.can-08-0348
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发表时间：
2008-08-15
期刊：
影响因子：
11.2
通讯作者：
Douglas, Julie A.
中科院分区：
文献类型：
--
作者：
Levin, Albert M.;Machiela, Nlitchell J.;Douglas, Julie A.
In a recent genome-wide association study by Gudmundsson and colleagues, two prostate cancer susceptibility loci were identified on chromosome 17q. The first locus, at 17q12, was distinguished by two intronic single-nucleotide polymorphisms (SN-Ps) in the TCF2 gene (rs4430796 and rs7501939). The second locus was in a gene-poor region of 17q24, where the strongest evidence of association was for SNIP rs1859962. To determine if these loci were also associated with hereditary prostate cancer, we genotyped them in a family-based association sample of 403 non-Hispanic white families, including 1,015 men with and without prostate cancer. SNPs rs4430796 and rs7501939, which were in strong linkage disequilibrium (r(2) = 0.68), showed the strongest evidence of prostate cancer association. Using a family-based association test, the A allele of SNP rs4430796 was overtransmitted to affected men (P = 0.006), with an odds ratio of 1.40 (95% confidence interval, 1.09-1.81) under an additive genetic model. Notably, rs4430796 was significantly associated with prostate cancer among men diagnosed at an early (
