Prenatal and childhood exposure to phthalate diesters and neurobehavioral development in a 15-year follow-up birth cohort study
Prenatal and childhood exposure to phthalate diesters and neurobehavioral development in a 15-year follow-up birth cohort study
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DOI：
10.1016/j.envres.2019.02.029
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发表时间：
2019-05-01
影响因子：
8.3
通讯作者：
Wang, Shu-Li
中科院分区：
文献类型：
--
作者：
Huang, Han-Bin;Kuo, Po-Hsiu;Wang, Shu-Li
目的：关于学龄儿童和青少年神经行为发育与产前和产后邻苯二甲酸酯暴露相关的纵向研究有限。我们调查了产前和儿童期邻苯二甲酸酯暴露与8-14岁儿童行为综合征的发展之间的关系。方法：我们从2000年至2001年招募了430名孕妇，并在2岁，5岁，8岁，11岁和14岁时随访了她们的孩子，共产生153对母子。分析了妊娠晚期孕妇和2-8岁儿童的尿液样本中7种尿邻苯二甲酸酯代谢物的浓度：邻苯二甲酸单甲酯、邻苯二甲酸单乙酯、邻苯二甲酸单丁酯、邻苯二甲酸单苄酯（MBzP）和三种二邻苯二甲酸（2-乙基己基）酯（DEHP）代谢产物，即邻苯二甲酸单-2-乙基己基酯（MEHP）、邻苯二甲酸（2-乙基-5-羟己基）酯和邻苯二甲酸单（2-乙基-5-氧代己基）酯。使用儿童行为检查表评估8-14岁儿童的行为综合征。我们构建了混合模型，以检查这些协会调整后的潜在covariates.Results：产妇尿MEHP水平与较高的得分为内在的问题（β = 0.028，95%置信区间[CI]：0.0004，0.055）和外在的问题（β = 0.040，95% CI：0.013，0.066）。母体尿液DEHP代谢物水平总和与不良行为评分和外化问题评分呈正相关（不良行为的β = 0.035，95% CI：0.013，0.057;外化问题的β = 0.026，95% CI：0.001，0.050）。此外，儿童的尿MBzP水平与较高的社会问题评分相关（β = 0.018，95%CI：0.001，0.035）。观察到类似的模式的边界和临床ranges.Conclusion：早期生活中暴露于邻苯二甲酸酯可能会影响儿童行为综合征的发展。未来的研究需要复制这些发现，并努力减少在关键的早期生命阶段邻苯二甲酸酯的暴露可能是必要的。
Objective: Longitudinal studies on neurobehavioral development in relation to prenatal and postnatal exposure to phthalates in school-age children and adolescents are limited. We investigated the association of prenatal and childhood phthalate exposure with the development of behavioral syndromes in 8-14-year-old children.Method: We recruited 430 pregnant women from 2000 to 2001 and followed their children at the ages of 2, 5, 8, 11, and 14 years, yielding 153 mother-child pairs in total. Urine samples from pregnant women in the third trimester and from children at 2-8 years of age were analyzed for the concentrations of seven urinary phthalate metabolites: monomethyl phthalate, monoethyl phthalate, monobutyl phthalate, monobenzyl phthalate (MBzP), and three di(2-ethylhexyl) phthalate (DEHP) metabolites, namely mono-2-ethylhexyl phthalate (MEHP), mono (2-ethyl-5-hydroxyhexyl) phthalate, and mono(2-ethyl-5-oxohexyl) phthalate. Behavioral syndromes in children aged 8-14 years were assessed using the Child Behavior Checklist. We constructed mixed models to examine these associations after adjustments for potential covariates.Results: Maternal urinary MEHP levels were associated with higher scores for internalizing problems ((beta = 0.028, 95% confidence interval [CI]: 0.0004, 0.055) and externalizing problems (beta = 0.040, 95% CI: 0.013, 0.066). Associations of the maternal urinary sum of DEHP metabolite levels with delinquent behavior scores and externalizing problems scores were positive (beta = 0.035, 95% CI: 0.013, 0.057 for delinquent behavior; beta = 0.026, 95% CI: 0.001, 0.050 for externalizing problems). Furthermore, children's urinary MBzP levels were associated with higher scores for social problems (beta = 0.018, 95% CI: 0.001, 0.035). Similar patterns were observed for borderline and clinical ranges.Conclusion: Early-life exposure to phthalates may influence behavioral syndrome development in children. Future studies are needed to replicate these findings, and efforts to reduce exposures to phthalates during critical early life stages may be warranted.