Addition of Degenerate Bases to DNA-based Data Storage for Increased Information Capacity
Addition of Degenerate Bases to DNA-based Data Storage for Increased Information Capacity
复制标题
将简并碱基添加到基于 DNA 的数据存储中以增加信息容量
DOI：
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Sunghoon Kwon
中科院分区：
文献类型：
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作者：
Yeongjae Choi;Taehoon Ryu;A. C. Lee;Hansol Choi;Hansaem Lee;Jaejun Park;Suk;Seoju Kim;Hyeli Kim;W. Park;Sunghoon Kwon
基于 DNA 的数据存储已成为满足呈指数级增长的信息存储需求的一种有前途的方法。然而，由于每单位数据的 DNA 成本很高，基于 DNA 的数据存储的实际实施仍然是一个挑战。在这里，我们提出除了A、C、G和T之外还使用11个简并碱基作为编码字符，这增加了信息容量（设计的每长度DNA序列可以存储的数据量）并降低了每单位数据的DNA成本。使用所提出的方法，我们通过实验实现了 3.37 位/字符的信息容量，比之前实现的最高信息容量增加了一倍多。最后，该平台预计可将基于 DNA 的数据存储成本降低 50%。
DNA-based data storage has emerged as a promising method to satisfy the exponentially increasing demand for information storage. However, practical implementation of DNA-based data storage remains a challenge because of the high cost of DNA per unit data. Here, we propose the use of eleven degenerate bases as encoding characters in addition to A, C, G, and T, which increases the information capacity (the amount of data that can be stored per length of DNA sequence designed) and reduce the cost of DNA per unit data. Using the proposed method, we experimentally achieved an information capacity of 3.37 bits/character, which is more than twice when compared to the highest information capacity previously achieved. Finally, the platform was projected to reduce the cost of DNA-based data storage by 50%.