Emerging role of antioxidants in the protection of uveitis complications.
Emerging role of antioxidants in the protection of uveitis complications.
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DOI：
10.2174/092986711794927694
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发表时间：
2011
影响因子：
4.1
通讯作者：
Ramana KV
中科院分区：
文献类型：
--
作者：
Yadav UC;Kalariya NM;Ramana KV
目前对氧化应激在眼部炎症性疾病中的作用的理解表明，抗氧化治疗可能对优化治疗很重要。最近研究的用于眼部炎性疾病的抗氧化剂疗法包括各种维生素、植物产品和活性氧清除剂。氧化应激在非感染性和感染性葡萄膜炎并发症中起着致病作用，用抗氧化剂治疗减少组织损伤和功能障碍的新策略可能会改善视觉并发症。实验动物和细胞培养的临床前研究证明了一些有前途的抗氧化剂的抗炎作用的重要性。这些抗氧化剂中的许多正在进行临床试验，用于治疗除葡萄膜炎以外的各种炎症性疾病，如心血管疾病、类风湿性关节炎和癌症。有必要对眼部炎症进行精心计划的干预性临床研究，以充分研究抗氧化剂治疗葡萄膜炎的潜在医疗益处。本文综述了近年来新型抗氧化剂治疗眼部炎症的研究进展，并重点介绍了葡萄膜炎的相关研究。
Current understanding of the role of oxidative stress in ocular inflammatory diseases indicates that antioxidant therapy may be important to optimize the treatment. Recently investigated antioxidant therapies for ocular inflammatory diseases include various vitamins, plant products and reactive oxygen species scavengers. Oxidative stress plays a causative role in both non-infectious and infectious uveitis complications, and novel strategies to diminish tissue damage and dysfunction with antioxidant therapy may ameliorate visual complications. Preclinical studies with experimental animals and cell culture demonstrate significance of anti-inflammatory effects of a number of promising antioxidant agents. Many of these antioxidants are under clinical trial for various inflammatory diseases other than uveitis such as cardiovascular, rheumatoid arthritis and cancer. Well planned interventional clinical studies of the ocular inflammation will be necessary to sufficiently investigate the potential medical benefits of antioxidant therapies for uveitis. This review summarizes the recent investigation of novel antioxidant agents for ocular inflammation, with selected studies focused on uveitis.