Fast positive feedback between the adrenocortical stress response and a brain mechanism involved in aggressive behavior
Fast positive feedback between the adrenocortical stress response and a brain mechanism involved in aggressive behavior
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DOI：
10.1037/0735-7044.118.5.1062
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发表时间：
2004-10-01
影响因子：
1.9
通讯作者：
Haller, J
中科院分区：
文献类型：
--
作者：
Kruk, MR;Halász, J;Haller, J
攻击性行为会引发肾上腺皮质应激反应，而突如其来的压力源往往会引发暴力行为。在大鼠身上的实验表明，肾上腺皮质应激反应和控制攻击的大脑机制之间存在快速、相互的正反馈。刺激下丘脑的攻击区迅速激活肾上腺皮质反应，即使在没有对手和打斗的情况下也是如此。在大鼠体内注射皮质酮，通过肾上腺切除来防止自然的肾上腺皮质应激反应，进而迅速促进下丘脑的攻击。这两种影响的迅速都表明，在单一冲突的时间框架内，控制机制迅速、相互、积极地反馈。这种相互促进可能有助于在应激条件下暴力行为的沉淀和升级。
Aggressive behavior induces an adrenocortical stress response, and sudden stressors often precipitate violent behavior. Experiments in rats revealed a fast, mutual, positive feedback between the adrenocortical stress response and a brain mechanism controlling aggression. Stimulation of the aggressive area in the hypothalamus rapidly activated the adrenocortical response, even in the absence of an opponent and fighting. Hypothalamic aggression, in turn, was rapidly facilitated by a corticosterone injection in rats in which the natural adrenocortical stress response was prevented by adrenalectomy. The rapidity of both effects points to a fast, mutual, positive feedback of the controlling mechanisms within the time frame of a single conflict. Such a mutual facilitation may contribute to the precipitation and escalation of violent behavior under stressful conditions.