Maternal magnesium supplementation reduces intrauterine growth restriction and suppresses inflammation in a rat model
Maternal magnesium supplementation reduces intrauterine growth restriction and suppresses inflammation in a rat model
复制标题
DOI：
10.1016/j.ajog.2013.03.001
复制
发表时间：
2013-05-01
影响因子：
9.8
通讯作者：
Metz, Christine N.
中科院分区：
文献类型：
--
作者：
Roman, Amanda;Desai, Neeraj;Metz, Christine N.
OBJECTIVE: Intrauterine growth restriction (IUGR) is associated with increased inflammatory responses. We sought to investigate whether magnesium (Mg) attenuates inflammation and IUGR in a rat model.STUDY DESIGN: Pregnant Wistar rats (12 weeks, gestational day 18) were randomly assigned to 1 of 4 groups: normal diet with bilateral uterine artery ligation (BL) (n = 6) or sham surgery (SH) (n = 5); and Mg chloride (MgCl2) 1% (wt/vol) in the drinking water throughout gestation + BL (MgBL) (n = 6) or SH (MgSH) (n = 5). Dams were euthanized 24 hours postsurgery (gestational day 19). Maternal plasma, fetal plasma (pooled), individual amniotic fluid (AF) samples, and placentas (PL) were collected and assessed from live fetal pups only (BL, n = 36; SH, n = 20; MgBL, n = 20; MgSH, n = 20). All samples were analyzed for cytokines/chemokines (interleukin [IL] 6, IL 1 beta, chemokine [C X C motif] ligand 1 [CXCL1], chemokine [C C motif] ligand 2 [CCL2], and tumor necrosis factor [TNF alpha] sensitivity
