Central nervous system distribution of fibroblast growth factor injected into the blood stream.
Central nervous system distribution of fibroblast growth factor injected into the blood stream.
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DOI：
10.1080/01616412.1996.11740418
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发表时间：
1996-06
影响因子：
1.9
通讯作者：
P. Cuevas;A. Fernández-Ayerdi;F. Carceller;S. Colin;F. Mascarelli;I. Muñoz-Willery;G. Giménez-Gallego
中科院分区：
文献类型：
--
作者：
P. Cuevas;A. Fernández-Ayerdi;F. Carceller;S. Colin;F. Mascarelli;I. Muñoz-Willery;G. Giménez-Gallego
已有研究表明，无论是脑室注射还是静脉注射，成纤维细胞生长因子(FGFs)都能保护下丘脑CA1细胞免受短暂性缺血的影响。全身治疗的有效性似乎表明，FGFs在一定程度上越过了血脑屏障。用~(14)C均匀标记制剂对全身给药后大鼠中枢神经系统内碱性成纤维细胞生长因子(BFGF)的出现进行了放射自显影检查。我们的结果显示，在全身给药两小时后，碱性成纤维细胞生长因子在除神经胶质细胞外的几种神经细胞和非神经细胞中都有分布。当14C-bFGF在全身注射前加热或与过量的未标记bFGF联合给药时，标记积累是不可察觉的。我们的结果表明，存在一个可饱和的FGFs跨越血脑屏障的运输系统。
It has been shown that fibroblast growth factors (FGFs) protect hypocampal CAI cells from the effects of transient ischemia when injected either intraventrically or intravenously. The effectiveness of the systemic treatment seems to suggest that FGFs cross the blood-brain barrier to some extent. The appearance of basic fibroblast growth factor (bFGF) in the rat central nervous system after systemic administration have been autoradiographically examined using a 14C uniformly labeled preparation. Our results show that, two hours after a systemic bolus administration, bFGF spots in several populations of neuronal and in non-neural cells except in glial cells. Label accumulation was imperceptible when either 14C-bFGF was heated previously to the systemic injection or was co-administered with an excess of unlabeled bFGF. Our results indicate the existence of a saturable transport system of FGFs across the blood-brain barrier.