DOPAMINE D2 RECEPTOR-BINDING AND CEREBRAL GLUCOSE-METABOLISM RECOVER AFTER D-PENICILLAMINE-THERAPY IN WILSONS-DISEASE
DOPAMINE D2 RECEPTOR-BINDING AND CEREBRAL GLUCOSE-METABOLISM RECOVER AFTER D-PENICILLAMINE-THERAPY IN WILSONS-DISEASE
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DOI：
10.1007/bf00920620
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发表时间：
1994-10-01
影响因子：
6
通讯作者：
SEITZ, RJ
中科院分区：
文献类型：
--
作者：
SCHLAUG, G;HEFTER, H;SEITZ, RJ
使用正电子发射断层扫描和 F-18-脱氧葡萄糖和 F-18-甲基螺哌隆 ([F-18]MSP) 分别测量了一名 31 岁、严重受影响、未经治疗的患有威尔逊氏病 3 年的患者的区域脑葡萄糖代谢 (rCMRGlc) 和多巴胺 D2 受体结合。纹状体和纹状体外 rCMRGlc 以及纹状体 [F-18]MSP 积累率严重降低。 D-青霉胺治疗1年后，纹状体和纹状体外rCMRGlc和纹状体[F-18]MSP积累率几乎达到正常水平。据推测，铜捕获疗法导致的运动功能恢复与基底神经节活性的增加以及多巴胺 D2 受体的重新表达或上调有关。
Regional cerebral glucose metabolism (rCMRGlc) and dopamine D2 receptor binding were measured in a 31-year-old, severely affected, untreated patient with Wilson's disease of 3 years' duration using positron emission tomography and F-18-deoxyglucose and F-18-methylspiperone ([F-18]MSP), respectively. There was a severe reduction of striatal and extrastriatal rCMRGlc as well as of striatal [F-18]MSP accumulation rate. After 1 year of treatment with D-penicillamine, striatal and extrastriatal rCMRGlc and striatal [F-18]MSP accumulation rate reached almost normal levels. It is hypothesized that recovery of motor functions due to copper trapping therapy was associated with an increase in basal ganglia activity and a re-expression or upregulation of dopamine D2 receptors.