Dyshormonogenetic goitre with clear cell change resembling parathyroid adenoma--a case report.
Dyshormonogenetic goitre with clear cell change resembling parathyroid adenoma--a case report.
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激素性甲状腺肿伴透明细胞改变，类似于甲状旁腺腺瘤——病例报告。
DOI：
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发表时间：
1998
影响因子：
1
通讯作者：
A. Phatak
中科院分区：
文献类型：
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作者：
V. Kavishwar;A. Phatak
激素生成异常是甲状腺肿的罕见原因。它是控制参与甲状腺激素合成的蛋白质的基因突变的表现。尽管生化和临床表现多种多样，但所有缺陷的病理特征都是相似的。具有最小退行性改变和缺乏淋巴细胞浸润的非包膜结节是重要的诊断特征。本例中所见的透明细胞改变很常见，需要与甲状旁腺腺瘤相鉴别。细胞增多伴细胞异型性不应导致恶性肿瘤的误诊。
Dyshormonogenesis is a rare cause of goitre. It is manifestation of mutation in genes controlling the proteins involved in synthesis of thyroid hormones. Though there is wide spectrum of biochemical and clinical presentation, pathological features are similar in all defects. Nonencapsulated nodules with minimal regressive changes and lack of lymphocytic infiltration are important diagnostic features. Clear cell change as seen in this case is common and needs to be differentiated from parathyroid adenoma. Hypercellularity with cellular atypia should not lead to misdiagnosis of malignancy.