Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time
Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time
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DOI：
10.3945/ajcn.2010.29413
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发表时间：
2010-08-01
影响因子：
7.1
通讯作者：
Morris, Martha Clare
中科院分区：
文献类型：
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作者：
Skarupski, Kimberly A.;Tangney, Christine;Morris, Martha Clare
背景资料：B族维生素缺乏与抑郁症有关;然而，很少有前瞻性证据来自老年人的人群研究。目的：我们研究了维生素B-6、叶酸或维生素B-12的饮食摄入量是否可预测社区老年人平均7.2年以上的抑郁症状。设计：研究样本包括来自芝加哥健康与老龄化项目的3503名成年人，该项目是一项正在进行的、基于人群的、在年龄≥ 65岁的成年人中进行的双胞胎（59%非裔美国人）研究。膳食评估采用食物频率问卷。根据流行病学研究中心抑郁量表的10项版本中≥ 4项抑郁症状的存在来测量抑郁事件。使用广义估计方程的逻辑回归模型显示，较高的总摄入量，包括补充剂，维生素B-6和B-12的摄入与抑郁症发病率的降低相关，在调整了年龄，性别，种族，教育，收入，和抗抑郁药物的使用。例如，每增加10毫克维生素B-6和10微克维生素B-12，每年抑郁症状的几率降低2%。抑郁症状与这些维生素或叶酸的食物摄入量之间没有关联。这些协会仍然调整后吸烟，饮酒，丧偶，丧偶状态，认知功能，身体残疾，和医疗conditions.Conclusion：我们的研究结果支持的假设，高总摄入量的维生素B-6和B-12是保护抑郁症状随着时间的推移，在社区居住的老年人。美国临床营养杂志2010; 92：330-5.
Background: B-vitamin deficiencies have been associated with depression; however, there is very little prospective evidence from population-based studies of older adults.Objective: We examined whether dietary intakes of vitamins B-6, folate, or vitamin B-12 were predictive of depressive symptoms over an average of 7.2 y in a community-based population of older adults.Design: The study sample consisted of 3503 adults from the Chicago Health and Aging project, an ongoing, population-based, biracial (59% African American) study in adults aged >= 65 y. Dietary assessment was made by food-frequency questionnaire. Incident depression was measured by the presence of >= 4 depressive symptoms from the 10-item version of the Center for Epidemiologic Studies Depression scale.Results: The logistic regression models, which used generalized estimating equations, showed that higher total intakes, which included supplementation, of vitamins B-6 and B-12 were associated with a decreased likelihood of incident depression for up to 12 y of follow-up, after adjustment for age, sex, race, education, income, and antidepressant medication use. For example, each 10 additional milligrams of vitamin B-6 and 10 additional micrograms of vitamin B-12 were associated with 2% lower odds of depressive symptoms per year. There was no association between depressive symptoms and food intakes of these vitamins or folate. These associations remained after adjustment for smoking, alcohol use, widowhood, caregiving status, cognitive function, physical disability, and medical conditions.Conclusion: Our results support the hypotheses that high total intakes of vitamins B-6 and B-12 are protective of depressive symptoms over time in community-residing older adults. Am J Clin Nutr 2010; 92: 330-5.