Diet and colorectal adenoma in Japanese males and females
Diet and colorectal adenoma in Japanese males and females
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DOI：
10.1007/bf02234831
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发表时间：
2001-01-01
影响因子：
3.9
通讯作者：
Matsushita, S
中科院分区：
文献类型：
--
作者：
Nagata, C;Shimizu, H;Matsushita, S
目的：本研究的目的是评估结直肠腺瘤的风险与营养素和食物摄入量之间的关系。方法：1992年，在日本高山研究的一个队列中，通过半定量食物频率问卷对饮食进行评估。患者为181名男性和98名女性队列成员，他们在1993年1月1日至1995年12月31日期间在结肠镜检查中新被组织学证实患有结直肠腺瘤。对照组为12，607名男性和15，754名女性，他们在基线（1992年）没有结直肠息肉，腺瘤和癌症病史，并且在随访期间未被诊断患有这些疾病。研究结果：在男性中，腺瘤的风险与动物蛋白和维生素A的摄入量显著相关（相对风险，1.42; 95%置信区间，1.00-2.04;相对风险，1.51; 95%置信区间，1.04-2.20，分别为最高和最低三分位数;在控制了年龄、吸烟年限和饮酒量后，趋势P值分别为0.048和0.03。在控制协变量后，观察到碳水化合物摄入量的显著负相关（相对风险，0.52;最高与最低三分位数的95%置信区间，0.32-0.82;趋势P = 0.02）。动物脂肪和胆固醇的摄入与腺瘤的风险略有相关。结论：一些饮食成分，如动物蛋白质和碳水化合物，与西方人群中结直肠腺瘤或癌症的风险相关，也与日本人群中结直肠腺瘤的风险相关。
PURPOSE: The purpose of this study was to assess the relationship between risk of colorectal adenoma and dietary intake of nutrients and foods. METHODS: In 1992, diet was assessed by a semiquantitative food-frequency questionnaire in a cohort of the Takayama Study in Japan. Patients were 181 male and 98 female cohort members who were newly histologically proved to have colorectal adenoma at colonoscopic examination between January 1, 1993, and December 31, 1995. Controls were 12,607 males and 15,754 females who had no history of colorectal polyp, adenoma, and cancer at baseline (1992) and were not diagnosed to have these diseases during the follow-up period. RESULTS: In males, the risk of adenoma was significantly associated with intake of animal protein and vitamin A (relative risk, 1.42; 95 percent confidence interval, 1.00-2.04; and relative risk, 1.51; 95 percent confidence interval, 1.04-2.20, for the highest vs. lowest tertiles, respectively; P for trend = 0.048 and 0.03, respectively) after controlling for age, years of smoking, and alcohol intake. A significantly inverse association was observed for carbohydrate intake after controlling for the covariates (relative risk, 0.52; 95 percent confidence interval, 0.32-0.82, for the highest vs. Lowest tertiles; P for trend = 0.02). Intakes of animal fat and cholesterol were marginally associated with risk of adenoma. CONCLUSION: Some dietary components such as animal protein and carbohydrate, which have been associated with risk of colorectal adenoma or cancer in western populations, were also associated with risk of colorectal adenoma in the Japanese population.