Do subjective cognitive complaints correlate with cognitive impairment in systemic lupus erythematosus? A Danish outpatient study
Do subjective cognitive complaints correlate with cognitive impairment in systemic lupus erythematosus? A Danish outpatient study
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DOI：
10.1177/0961203310382430
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发表时间：
2011-01-01
期刊：
影响因子：
2.6
通讯作者：
Jacobsen, S.
中科院分区：
文献类型：
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作者：
Vogel, A.;Bhattacharya, S.;Jacobsen, S.
本研究调查了丹麦系统性红斑狼疮（SLE）门诊患者认知功能障碍的患病率及其与抑郁症状和自我报告的认知功能障碍的相关性。采用综合神经心理测验、自填式知觉缺陷问卷（PDQ）和抑郁自评量表（Major Depression Inventory）对57例女性SLE门诊患者进行了测试。22例患者（38.5%）被归类为认知功能受损，大多数执行功能和注意力缺陷。在认知障碍患者中，只有18.2%的患者PDQ评分显著高于正常范围。PDQ得分与抑郁症状高度相关（r = 0.67，p < 0.001）。只有两项神经心理学测试与主观认知抱怨显著相关。当这些变量和自评抑郁得分进入回归模型，抑郁得分和符号数字模式测试的性能显着相关的PDQ得分。总之，认知障碍在这组（轻度）SLE门诊患者中很常见，但即使在认知障碍患者中，显著的主观认知主诉水平也很低。情感状态对认知功能的主观体验的影响甚至超过认知功能本身，没有主观认知主诉并不排除存在认知障碍。狼疮（2011）20，35-43。
This study examined the prevalence of cognitive impairment and its association with depressive symptoms and self-reported cognitive complaints in Danish outpatients with systemic lupus erythematosus (SLE). Fifty-seven consecutive female SLE-outpatients were examined with a comprehensive neuropsychological test-battery, a 20-item self-administered Perceived Deficits Questionnaire (PDQ) and a self-rated depression scale (Major Depression Inventory). Twenty-two patients (38.5%) were classified as cognitively impaired, mostly with deficits in executive functions and attention. Among cognitively impaired patients only 18.2% had significantly higher PDQ scores than the normal range. PDQ scores were highly correlated to depressive symptoms (r = 0.67, p < 0.001). Only two neuropsychological tests were significantly correlated with subjective cognitive complaints. When these variables and self-rated depression score were entered into a regression model both depression score and Symbol Digit Modalities Test performances were significantly associated with the PDQ score. In conclusion, cognitive impairments were common in this group of (mild) SLE outpatients, but the level of significant subjective cognitive complaints was low even among patients with cognitive impairment. Affective status may influence subjective experience of cognitive functions even more than cognitive functioning itself, and absence of subjective cognitive complaints did not exclude the presence of cognitive impairments. Lupus (2011) 20, 35-43.