Cancer case-control studies with other cancers as controls.
Cancer case-control studies with other cancers as controls.
复制标题
以其他癌症作为对照的癌症病例对照研究。
DOI：
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发表时间：
1988
影响因子：
7.7
通讯作者：
P. Callas
中科院分区：
文献类型：
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作者：
Allan H. Smith;N. Pearce;P. Callas
本文综述了在癌症病例对照研究中使用其他癌症患者作为对照的理论考虑。选择偏差可能是一个问题，因为其他一些癌症可能是由研究中的暴露引起的，使比值比偏向于1。这种偏差在低流行率暴露与其他癌症的高归因风险相关的情况下最大。然而，使用人口普查或其他一般人群数据，可能会发现与其他癌症对照的选择偏倚。此外，使用其他癌症作为对照在回忆和访谈者偏差方面具有重要优势，当使用一般人群对照时，这可能是未知的幅度和方向。一般人群对照的另一个缺点是，对于死亡病例，通常应单独选择减少的对照，而当选择其他癌症患者作为对照时，可以预期活的和死亡的对照的混合物。由于使用其他癌症患者作为对照也具有后勤和成本优势，因此这种研究设计可能会在未来越来越多地使用，特别是在癌症登记设置中。
Theoretical considerations concerning the use of other cancer patients as controls in cancer case-control studies are reviewed. Selection bias may be a problem in that some other cancers may be caused by the exposure under study biasing the odds ratio towards unity. Such bias is noted to be greatest with low prevalence exposures associated with high attributable risks for other cancers. However, it may be possible to identify selection bias with other cancer controls using census or other general population data. In addition, using other cancers as controls has important advantages with regard to recall and interviewer bias, which may be of unknown magnitude and direction when using general population controls. A further disadvantage of general population controls is that separate selection of decreased controls should usually be made for deceased cases, whereas a mixture of live and deceased controls can be expected when selecting other cancer patients as controls. Since there are also logistical and cost advantages in using other cancer patients as controls, this study design is likely to be used increasingly in the future, particularly in cancer registry settings.