Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience
Laryngeal Cancer Attributable Factors and the Influence on Survival Rates:A Single Brazilian Institution Experience
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DOI：
10.1055/s-0039-1687909
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发表时间：
2019-09-01
影响因子：
1.1
通讯作者：
Macedo, Leandro Dorigan de
中科院分区：
文献类型：
--
作者：
Innocentini, Lara Maria Alencar Ramos;Teixeira, Alisson Henrique;Macedo, Leandro Dorigan de
流行病学研究集中在与喉癌相关的预后因素在巴西人口的文献报道很少。目的探讨喉部鳞状细胞癌（SCC）的危险因素对患者生存率的影响。方法对某三级医院头颈科门诊收治的成年患者进行回顾性研究。根据年龄、性别、发病阶段、发病时间、生活习惯、文化程度、复发及死亡等因素，对住院喉部鳞状细胞癌患者生存率的影响进行评估。采用Kaplan-Meier法、Log-rank检验和Cox回归分析总生存期（OS）、无病生存期（DFS）和临床人口学数据。结果共纳入107例患者，平均年龄59.8岁，年龄范围19 ~ 81岁。III期和IV期与DFS （p = 0.02）和OS （p = 0.02）降低相关。吸烟患者比不吸烟患者有更长的疾病演变期（p = 0.003）。与不饮酒的吸烟者相比，吸烟者饮酒的死亡风险增加了2.8 （p = 0.002）。男性患者的DFS平均值低于女性患者（p = 0.04）。结论我们的研究证实，男性、吸烟并饮酒习惯和晚期与预后不良密切相关。
Introduction Epidemiological studies focused on prognostic factors associated with laryngeal cancer in the Brazilian population are poorly reported in the literature. Objective To evaluate the influence of certain risk factors on the survival rates of patients with squamous cell carcinoma (SCC) of the larynx. Methods This retrospective study was conducted on adult patients who were admitted to the outpatient clinic of the head and neck department in a tertiary care hospital. Evaluation of the influence of risk factors on the survival rates of patients registered in the hospital with laryngeal SCC was performed based on age, sex, initial stage, time of evolution, habits, educational levels and relapse and death. Overall survival (OS), disease-free survival (DFS) and clinical-demographic data were analyzed using the Kaplan-Meier method, Log-rank test and Cox regression. Results A total of 107 patients with a mean age of 59.8 years (range 19-81) were included in this study. Stages III and IV were associated with decreased DFS ( p = 0.02) and OS ( p = 0.02). Smoking patients had a greater period of disease evolution than non-smoking patients ( p = 0.003). Alcohol consumption in smokers increased the risk of death by 2.8 ( p = 0.002) compared with non-drinking smokers. Male patients presented lower DFS average when compared with female patients ( p = 0.04). Conclusion Our study confirms that male gender, smoking habit combined with alcohol consumption, and advanced stages were strongly associated with poor prognosis.