Epigenetics in breast cancer: what's new?
Epigenetics in breast cancer: what's new?
复制标题
DOI：
10.1186/bcr2925
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Oesterreich S
中科院分区：
文献类型：
--
作者：
Huang Y;Nayak S;Jankowitz R;Davidson NE;Oesterreich S
表观遗传变化对于癌症（包括乳腺癌）的发生和进展至关重要。对于 DNA 甲基化、组蛋白修饰、miRNA 表达和高级染色质结构等各种表观遗传变化如何影响基因表达的基本理解已经取得了重大进展。本综述将重点关注组蛋白的甲基化和去甲基化。虽然组蛋白的乙酰化一直处于组蛋白翻译后修饰的最前沿，包括针对去乙酰化酶的抑制剂的开发，但在过去几年中，人们对组蛋白甲基化/去甲基化作用的了解急剧增加。这是一个令人兴奋且快速发展的研究领域，有望对包括乳腺癌在内的多种癌症进行潜在的临床干预。我们还总结了识别 DNA 甲基化特征的努力，这些特征可能是乳腺癌的预后和/或预测标记，重点关注最近使用全基因组方法的研究。最后，我们简要回顾了美国国立卫生研究院表观基因组项目和癌症基因组图谱所做的努力，特别强调了乳腺癌表观遗传学的研究、令人兴奋的技术进步、潜在的障碍和未来的方向。
Epigenetic changes are critical for development and progression of cancers, including breast cancer. Significant progress has been made in the basic understanding of how various epigenetic changes such as DNA methylation, histone modification, miRNA expression, and higher order chromatin structure affect gene expression. The present review will focus on methylation and demethylation of histones. While the acetylation of histones has been at the forefront of well-characterized post-translational modifications of histones, including the development of inhibitors targeting de-acetylating enzymes, the past few years have witnessed a dramatic increase in knowledge regarding the role of histone methylation/demethylation. This is an exciting and rapidly evolving area of research, with much promise for potential clinical intervention in several cancers including breast cancer. We also summarize efforts to identity DNA methylation signatures that could be prognostic and/or predictive markers in breast cancer, focusing on recent studies using genome-wide approaches. Finally, we briefly review the efforts made by both the National Institutes of Health Epigenome Project and The Cancer Genome Atlas, especially highlighting the study of breast cancer epigenetics, exciting technological advances, potential roadblocks, and future directions.
登录
查看更多内容
在Jurkat T细胞中与特殊富含富含富含良好的序列结合蛋白1（SATB1）结合的基因组序列与染色质环的底部的核基质紧密相关。
影响因子：
7.8
作者：
de Belle, I;Cai, ST;Kohwi-Shigematsu, T
通讯作者：
Kohwi-Shigematsu, T
影响因子：
64.5
作者：
Chen, Zhongzhou;Zang, Jianye;Zhang, Gongyi
通讯作者：
Zhang, Gongyi
影响因子：
64.5
作者：
Garcia-Bassets, Ivan;Kwon, Young-Soo;Rosenfeld, Michael G.
通讯作者：
Rosenfeld, Michael G.
影响因子：
50.3
作者：
Chang CJ;Yang JY;Xia W;Chen CT;Xie X;Chao CH;Woodward WA;Hsu JM;Hortobagyi GN;Hung MC
通讯作者：
Hung MC
DOI：
10.1007/s00432-008-0354-x
发表时间：
2008-08-01
影响因子：
3.6
作者：
Fan, Jiang;Yin, Wen-Jin;Shao, Zhi-Min
通讯作者：
Shao, Zhi-Min