T-CELL AND B-CELL FUNCTION IN ALCOHOLIC LIVER-DISEASE
T-CELL AND B-CELL FUNCTION IN ALCOHOLIC LIVER-DISEASE
复制标题
DOI：
10.1016/s0168-8278(86)80078-2
复制
发表时间：
1986-01-01
影响因子：
25.7
通讯作者：
WILLIAMS, R
中科院分区：
文献类型：
--
作者：
NOURIARIA, KT;ALEXANDER, GJM;WILLIAMS, R
酒精性肝损伤患者体内免疫球蛋白合成增加归因于B细胞的直接激活，尽管已确定淋巴细胞功能的其他缺陷提示更普遍的缺陷。在本研究中，我们已经调查了T细胞调节免疫球蛋白的产生在酒精性肝病中的作用，根据酒精性肝炎的存在或不存在进行分析。IgG和IgA的自发产生升高，并且共培养实验证实了B细胞的高反应性，但也表明T细胞功能受损。IgG和IgA的抑制细胞活性受损。同样，对美洲商陆有丝分裂原的IgG和IgA的反应是有缺陷的，虽然这是更显着的分泌比增殖提示相关的T辅助检测。酒精性肝炎和其他酒精性肝病患者的免疫学异常无差异。这项研究表明，在酒精性肝病患者中，无论肝脏炎症的严重程度如何，T细胞的广泛缺陷和B细胞的高反应性。
Increased in vivo synthesis of immunoglobulin in patients with alcoholic liver damage has been attributed to direct activation of B cells, although other defects of lymphocyte function have been identified suggesting a more generalised defect. In the present study we have investigated the role of T cell regulation of immunoglobulin production in alcoholic liver disease analysed according to the presence or absence of alcoholic hepatitis. Spontaneous production of IgG and IgA was elevated and co-culture experiments confirmed hyper-reactivity of B cells, but also suggested impaired T cell function. Suppressor cell activity for IgG and IgA was impaired. Similarly, the response to pokeweed mitogen for IgG and IgA was defective, although this was more marked for secretion than for proliferation suggesting an associated T helper detect. No differences in the immunological abnormalities were identified between those with alcoholic hepatitis and those with other alcoholic liver diseases. This study demonstrates a broad defect of T cells and a hyper-reactivity of B cells in patients with alcoholic liver disease, irrespective of the severity of hepatic inflammation.