ABNORMAL MATERNAL SERUM CHORIONIC-GONADOTROPIN LEVELS IN PREGNANCIES WITH FETAL CHROMOSOME-ABNORMALITIES
ABNORMAL MATERNAL SERUM CHORIONIC-GONADOTROPIN LEVELS IN PREGNANCIES WITH FETAL CHROMOSOME-ABNORMALITIES
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DOI：
10.1002/pd.1970070904
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发表时间：
1987-11-01
影响因子：
3
通讯作者：
JONES, OW
中科院分区：
文献类型：
--
作者：
BOGART, MH;PANDIAN, MR;JONES, OW
对25名妊娠18 ~ 25周染色体异常胎儿的妇女和74名正常妊娠妇女的血清进行了人绒毛膜促性腺激素（alpha-hCG）α亚基、人绒毛膜促性腺激素（hCG）和甲胎蛋白（AFP）测定。在24%的异常妊娠和676%的正常妊娠中观察到AFP水平低于中位数的0.5倍（MoM）或高于2.5MoM。在8%的异常者和2%的正常者中观察到低浓度的hCG（<0.25MoM），而在56%的异常者和1%的正常者中观察到高浓度的hCG（> 2.5MoM）。在28%的异常者中观察到升高的hCG-α（> 2·5 MoM），而在正常者中没有观察到升高的hCG-α。测定hCG-α或hCG水平升高导致68%的染色体异常胎儿的妊娠率被检出，假阳性率为1.35%，测定促性腺激素水平升高和降低导致76%的异常妊娠被检出，假阳性率为4.05%。母体血清样品中的α可以用作检测处于胎儿染色体异常风险的妊娠的筛选程序。
The alpha subunit of human chorionid gonadotropin (alpha-hCG), human chorionic gonadotropin (hCG) and alpha fetoprotein (AFP) were measured in the serum of 25 women with chromosomally abnormally fetuses between 18 and 25 weeks of gestation and in 74 normal pregnancies. AFP levels less than 0.cntdot.5 multiples of the median (MoM) or greater than 2.cntdot.5 MoM were observed in 24 per cent of the abnormal pregnancies and in 6.cntdot.76 per cent of the normal pregnancies. A low concentration of hCG (< 0.cntdot.25 MoM) was observed in 8 per cent of abnormals and in 2.cntdot.7 per cent of normals while an elevated concentration of hCG (> 2.cntdot.5 MoM) was observed in 56 per cent of abnormals and in 1.cntdot.35 per cent of normals. Elevated hCG-alpha (> 2.cntdot.5 MoM) was observed in 28 per cent of abnormals and in none of the normals. Determination of elevated levels of hCG-alpha or hCG resulted in detection of 68 per cent of pregnencies with chromosomally abnormal fetuses with a false positive rate of 1.cntdot.35 per cent. Determination of both elevated and depressed gonadotropin levels resulted in detection of 76 per cent of abnormal pregnancies with a false positive rate of 4.cntdot.05 per cent. Measurement of hCG and hCG-alpha in maternal serum samples can be used as a screening procedure for detecting pregnancies at risk for fetal chromosome abnormalities.