RESISTANCE OF ADULTS TO CHALLENGE WITH INFLUENZA-A WILD-TYPE VIRUS AFTER RECEIVING LIVE OR INACTIVATED VIRUS-VACCINE
RESISTANCE OF ADULTS TO CHALLENGE WITH INFLUENZA-A WILD-TYPE VIRUS AFTER RECEIVING LIVE OR INACTIVATED VIRUS-VACCINE
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DOI：
10.1128/jcm.23.1.73-76.1986
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发表时间：
1986-01-01
影响因子：
9.4
通讯作者：
MURPHY, BR
中科院分区：
文献类型：
--
作者：
CLEMENTS, ML;BETTS, RF;MURPHY, BR
在106例血清阴性（血凝抑制抗体滴度≤ 100 μ g/ml）的受试者中，将减毒的冷适应（ca）甲型流感H3 N2和H1N1病毒活疫苗抵抗接种后7个月用同源野生型病毒进行的实验性攻击的效力与许可的灭活病毒疫苗的效力进行比较。1：8）大学生。减毒活病毒疫苗与灭活疫苗诱导的抗病性相同。通过疫苗中发热或全身性疾病的减少来衡量疫苗效力，与对照组相比，ca H3 N2疫苗为100%，灭活H3 N2疫苗为84%，ca H1N1疫苗为79%，灭活H1N1疫苗为67%。较少的质子化被赋予对上呼吸道疾病，有50%和77%的保护在CA和灭活H3 N2疫苗接种者，分别，但没有保护在CA或灭活H1N1疫苗。与对照组相比，在ca和灭活疫苗接种者中，H1N1野生型病毒脱落的持续时间显著减少，但幅度不明显。相比之下，在ca疫苗接种者中观察到H3 N2病毒脱落的持续时间和幅度显著减少，但在灭活疫苗中没有观察到。在野生型病毒攻击后，活ca病毒疫苗接种者表现出至少与灭活病毒疫苗接种者一样大的抵抗力。这些观察结果表明，活病毒疫苗可能是一个令人满意的替代灭活疫苗的健康人。
The efficacy of live attenuated cold-adapted (ca) reassortant influenza A H3N2 and H1N1 virus vaccines against experimental challenge with homologous wild-type virus 7 months after vaccination was compared with that of licensed inactivated virus vaccine in 106 seronegative (hemagglutination-inhibiting antibody titer .ltoreq. 1:8) college students. The live attenuated virus vaccines induced as much resistance against illness as did the inactivated vaccine. Vaccine efficacy, measured by reduction in febrile or systemic illness in vaccines, compared with that in controls was 100% for ca H3N2 vaccine, 84% for inactivated H3N2 vaccine, 79% for ca H1N1 vaccine, and 67% for inactivated H1N1 vaccine. Less protonation was conferred against upper respiratory tract illness; there was 50 and 77% protection in ca and inactivated H3N2 vaccinees, respectively, but there was no protection in ca or inactivated H1N1 vaccinees. The duration, but not the magnitude, of H1N1 wild-type virus shedding in both ca and inactivated vaccinees was significantly reduced compared with controls. In contrast, a significant reduction in the duration and magnitude of H3N2 virus shedding was observed in ca vaccinees but not in inactivated vaccines. After wild-type virus challenge, live ca virus vaccinees demonstrated resistance at least as great 7 months postvaccination as did inactivated virus vaccinees. These observations indicate that live virus vaccines may be a satisfactory alternative to inactivated vaccines for healthy persons.