Effect of olprinone, phosphodiesterase III inhibitor, on cerebral blood flow assessed with technetium-99m-ECD SPECT.
Effect of olprinone, phosphodiesterase III inhibitor, on cerebral blood flow assessed with technetium-99m-ECD SPECT.
复制标题
使用 technetium-99m-ECD SPECT 评估磷酸二酯酶 III 抑制剂奥普利酮对脑血流的影响。
DOI：
10.1097/00005344-200003000-00012
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发表时间：
2000
影响因子：
3
通讯作者：
H. Matsuo
中科院分区：
文献类型：
--
作者：
Yang Yu;K. Mizushige;T. Ueda;Y. Nishiyama;M. Seki;T. Aoyama;M. Ohkawa;H. Matsuo
关于磷酸二酯酶III抑制剂对脑动脉的影响，临床报道很少。因此，我们使用了[99mTC]-ECD脑SPECT和超声方法来定量评估给予磷酸二酯酶III抑制剂奥普利酮后的脑和全身血流动力学。对15例(65+/-8岁，男/女=13/2)头颅CT无异常的患者，分别用~(99m)Tc-ECD脑SPECT和多普勒超声心动图测定脑血流量和心输出量。在基线和服用奥普利酮后重复测量。脑血流量(p=0.0007)和心输出量(p=0.001)显著增加，收缩压(p=0.02)和全身血管阻力(p=0.002)显著降低。脑血流量的增加与心输出量的增加之间没有明显的相关性。这些数据表明，奥普利酮对大脑动脉有直接的血管扩张作用，这与没有经历过中风的患者的心输出量增加几乎没有关系。
Few clinical reports exist regarding the effects of phosphodiesterase III inhibitors on cerebral arteries. Therefore we used a [99mTc]-ECD brain SPECT and an ultrasound method to quantitatively evaluate cerebral and systemic flow dynamics after the administration of olprinone, a phosphodiesterase III inhibitor. In 15 patients (65 +/- 8 years, M/F = 13/2) with no abnormalities on a brain computed tomography (CT), cerebral blood flow and cardiac output were measured using [99mTc]-ECD brain SPECT and Doppler echocardiography, respectively. Measurements were repeated at baseline and after the administration of olprinone. Significant increases in cerebral blood flow (p = 0.0007) and cardiac output (p = 0.001) were observed, and systolic blood pressure (p = 0.02) and systemic vascular resistance (p = 0.002) significantly decreased. No significant correlation between the increase in cerebral blood flow and the increase in cardiac output was observed. The data indicate that olprinone has a direct vasodilator effect on the cerebral artery, which was little related to the increase in cardiac output in patients who had not experienced stroke.
影响因子：
37.8
作者：
LEWIS, JF;KUO, LC;QUINONES, MA
通讯作者：
QUINONES, MA
米力农对豚鼠气管、肺实质和肺动脉收缩反应的影响。
DOI：
--
发表时间：
1986
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Rossing,TH;Drazen,JM
通讯作者：
Drazen,JM