Evaluation of clinical and clinical chemical parameters in periparturient cows
Evaluation of clinical and clinical chemical parameters in periparturient cows
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DOI：
10.3168/jds.s0022-0302(01)74610-3
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发表时间：
2001-07-01
影响因子：
3.5
通讯作者：
Bellio, R
中科院分区：
文献类型：
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作者：
Larsen, T;Moller, G;Bellio, R
某些血液参数和临床症状与奶牛的乳热病和低血钙症有关。本研究旨在建立相关血液参数与奶牛潜在有价值的背景信息以及产犊时观察到的临床症状之间的相互联系。两名兽医在201头母牛分娩后12小时内被召见，这些母牛分布在41个丹麦商业牛群中。奶牛处于不同的产次水平(2到10头)，品种和管理在不同的牛群中差别很大。从颈静脉或尾静脉采集血液样本，随后在实验室进行分析。此外，13种不同的临床症状被记录为分类数据。我们调查了获得的数据之间的关联。我们用血液参数和动物的背景知识对实际血钙水平的解释模型进行了评估。我们利用背景知识、血液参数和临床检查结果建立了通径分析，以揭示变量之间的因果关系，26%的动物被诊断为乳房热，随后的血液分析显示低钙血症的频率较高，一般范围为每升0.69至2.73 mmol钙。直肠温度、无机血磷和钾均与血钙呈正相关，而葡萄糖、乳酸和镁与钙呈负相关。低钙动物血中骨钙素水平显著降低，说明低钙血症时骨新生合成受阻，混合效应线性解释模型可解释75%的血钙变化。临床症状如情绪、食欲、肌肉颤抖、瘤胃运动和瘫痪分别与血钙相关，从而预测低钙血症，通径分析表明钙在影响临床症状中起核心作用。然而，其他几个因素也导致了低钙血症。
Certain blood parameters and clinical symptoms have been connected with milk fever and a hypocalcemic condition in the cow. The present study intended to establish a mutual connection between relevant blood parameters and potentially valuable background information about the cow and its observed clinical symptoms at calving. Two veterinarians were summoned within 12 h of parturition of 201 cows, distributed among 41 Danish commercial herds. Cows were at different parity levels (2 to 10) and breeds and management differed broadly among herds. A blood sample was taken from the vena jugularis or the tail vein and was subsequently analyzed in the laboratory. Furthermore, 13 different clinical symptoms were recorded as categorical data. We investigated associations among the data obtained. We assessed an interpretative model for actual blood calcium level with blood parameters and background knowledge of the animals. We established a path analysis using background knowledge, blood parameters, and results of clinical examinations to uncover causal connections among the variables,Twenty-six percent of the animals were diagnosed as having milk fever and subsequent blood analyses revealed a high frequency of hypocalcemia within the general range from 0.69 to 2.73 mmol of Ca per liter. Rectal temperature, inorganic blood phosphate, and potassium were all directly correlated with blood calcium, while glucose, lactate, and magnesium were inversely associated with calcium. Blood osteocalcin was significantly lower in hypocalcemic animals, indicating that de novo synthesis of bone was arrested during hypocalcemia, A mixed effect linear interpretative model explained 75% of the variation in blood calcium. Clinical symptoms like mood, appetite, muscle shivering, rumen motility, and paresis were individually correlated with blood calcium and were thereby predictive of hypocalcemia, The path analysis showed the central role of calcium in affecting the clinical symptoms. However, several other factors contributed to hypocalcemia.