Capsular polysaccharide serotyping scheme for Staphylococcus epidermidis
Capsular polysaccharide serotyping scheme for Staphylococcus epidermidis
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表皮葡萄球菌荚膜多糖血清分型方案
DOI：
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发表时间：
1992
影响因子：
9.4
通讯作者：
W. Karakawa
中科院分区：
文献类型：
--
作者：
A. Fattom;S. Shepherd;W. Karakawa
描述了一种基于蛋白酶处理的细菌细胞和特异性抗血清之间的直接玻片凝集的表皮葡萄球菌荚膜分型的方案。用两株荚膜链球菌免疫家兔，制备抗血清。从菌血症患者分离的表皮。抗血清显示为类型特异性的，并指定为1型和2型。血分离株S.对来自美国和欧洲不同地区医院的表皮葡萄球菌菌株进行血清分型，发现超过90%的所有菌株为1型或2型。型特异性抗体介导的型特异性调理吞噬作用和对S.表皮。特异性被证明是由于两种不同的荚膜多糖。本研究结果可能为S.这可能导致新疫苗和疗法的开发。
A scheme for the capsular typing of Staphylococcus epidermidis that is based on direct slide agglutination between proteinase-treated bacterial cells and specific antisera is described. Antisera were prepared from serum from rabbits immunized with two selected strains of encapsulated S. epidermidis isolated from bacteremic patients. Antisera were shown to be type specific and designated type 1 and type 2. Blood isolates of S. epidermidis from hospitals in different locations within the United States and Europe were serotyped, and it was found that over 90% of all strains were of type 1 or type 2. Type-specific antibodies mediated type-specific opsonophagocytosis and killing of S. epidermidis. The specificity was shown to be due to two distinct capsular polysaccharides. The data presented in this report may open a new window on the pathogenesis of S. epidermidis which could lead to the development of new vaccines and therapies.
荚膜多糖/粘附素抗体可保护兔子免受凝固酶阴性葡萄球菌引起的导管相关菌血症。
DOI：
10.1093/infdis/162.2.435
发表时间：
1990
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Kojima,Y;Tojo,M;Goldmann,DA;Tosteson,TD;Pier,GB
通讯作者：
Pier,GB